Ultrastructural Cytochemistry of Phosphatases in the Ductal Component of Pleomorphic Adenoma of Human Parotid and Submandibular Salivary Glands

Overview

Journal Histochem J

Specialty Biochemistry

Date 1982 Sep 1

PMID 6290430

Citations 6

Authors

J D Harrison

D W Auger

Affiliations

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Abstract

Some ductal cells of pleomorphic adenomas showed evidence of secretory activity, with apical secretory granules, thiamine pyrophosphatase activity in the Golgi apparatus, and acid phosphatase activity in GERL-like structures and in immature secretory granules. Alkaline phosphatase activity was demonstrated rarely at the luminal plasma membrane and in intracellular vesicles, suggesting resorptive activity. ATPase reaction product was associated with contiguous surfaces of tumour cells, particularly of those cells adjacent to the basement membrane, these latter cells apparently differentiating in a different manner to the luminal cells. A comparison of luminal ductal cells of the tumours with normal salivary glands revealed most similarity with intercalary ductal cells.

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Ultrastructural observations on luminal structures of pleomorphic adenoma of parotid and submandibular salivary glands of man.

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