Guanidine and Heat Sensitivity of Foot-and-mouth Disease Virus (FMDV) Strains

Overview

Journal J Hyg (Lond)

Publisher Cambridge University Press

Specialty Public Health

Date 1982 Aug 1

PMID 6284836

Citations 7

Authors

P F Nettleton

M J Davies

M M Rweyemamu

Affiliations

Soon will be listed here.

Abstract

A study of the ability of 49 strains of FMD virus to replicate in BHK-21 monolayer cells maintained under a standard agar overlay containing 5.2 mM guanidine hydrochloride and to withstand heat inactivation at 54 degrees C for 1 h showed that strains belonging to serotypes C, O and Asia 1 were generally more resistant to guanidine and heat stable than the SAT 1, 2 and 3 serotypes. The type A viruses as a whole occupied an intermediate position between these two groups. In vitro passage in BHK-21 cells influenced the guanidine sensitivity of 3(O, C and SAT 3) of the 7 FMD serotypes suggesting that this is not a stable genetic marker. Heat stability of the FMD viruses, however, did not change on passage, suggesting that this is a stable characteristic inherent in any homogeneous FMD virus population.

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References

Brown F, Wild T . The effect of heat on the structure of foot-and-mouth disease virus and the viral ribonucleic acid. Biochim Biophys Acta. 1966; 119(2):301-8. DOI: 10.1016/0005-2787(66)90188-2. View

Brown F, Martin S, Underwood B . A study of the kinetics of protein and RNA synthesis induced by foot-and-mouth disease virus. Biochim Biophys Acta. 1966; 129(1):166-77. DOI: 10.1016/0005-2787(66)90018-9. View

Black D, Brown F . Effect of actinomycin D and guanidine on the formation of a ribonucleic acid polymerase induced by foot-and mouth-disease virus and on the replication of virus and viral ribonucleic acid. Biochem J. 1969; 112(3):317-23. PMC: 1187710. DOI: 10.1042/bj1120317. View

Pringle C . Electrophoretic properties of foot-and-mouth disease virus strains and the selection of intra-strain mutants. J Gen Virol. 1969; 4(4):541-55. DOI: 10.1099/0022-1317-4-4-541. View

Cowan K . Antibody response to viral antigens. Adv Immunol. 1973; 17:195-253. DOI: 10.1016/s0065-2776(08)60733-6. View

Lake J, Priston A, SLADE W . A genetic recombination map of foot-and-mouth disease virus. J Gen Virol. 1975; 27(3):355-67. DOI: 10.1099/0022-1317-27-3-355. View

MacKenzie J, SLADE W . Evidence for recombination between two different immunological types of foot-and-mouth disease virus. Aust J Exp Biol Med Sci. 1975; 53(4):251-6. DOI: 10.1038/icb.1975.27. View

Nick H, Ahl R . Inhibitors of foot-and-mouth disease virus. Temperature-dependence of the effect of guanidine on virus growth. Arch Virol. 1976; 52(1-2):71-83. DOI: 10.1007/BF01317866. View

McCahon D, SLADE W, Priston R, Lake J . An extended genetic recombination map for foot-and-mouth diseases virus. J Gen Virol. 1977; 35(3):555-65. DOI: 10.1099/0022-1317-35-3-555. View

10.

Pereira H . Subtyping of foot-and-mouth disease virus. Dev Biol Stand. 1976; 35:167-74. View

11.

Robson K, Harris T, Brown F . An assessment by competition hybridization of the sequence homology between the RNAs of the seven serotypes of FMDV. J Gen Virol. 1977; 37(2):271-6. DOI: 10.1099/0022-1317-37-2-271. View

12.

Rweyemamu M, BOOTH J, Head M, PAY T . Microneutralization tests for serological typing and subtyping of foot-and-mouth disease virus strains. J Hyg (Lond). 1978; 81(1):107-23. PMC: 2129748. DOI: 10.1017/s002217240005381x. View

13.

Rweyemamu M, Terry G, PAY T . Stability and immunogenicity of empty particles of foot-and-mouth disease virus. Arch Virol. 1979; 59(1-2):69-79. DOI: 10.1007/BF01317896. View

14.

Doel T, Baccarini P . Thermal stability of foot-and-mouth disease virus. Arch Virol. 1981; 70(1):21-32. DOI: 10.1007/BF01320790. View

15.

Brown F, Crick J . Application of agar gel precipitin tests to the study of the virus of foot-and-mouth disease. Virology. 1958; 5(1):133-44. DOI: 10.1016/0042-6822(58)90010-2. View

16.

CAPSTICK P, TELLING R, Chapman W, Stewart D . Growth of a cloned strain of hamster kidney cells in suspended cultures and their susceptibility to the virus of foot-and-mouth disease. Nature. 1962; 195:1163-4. DOI: 10.1038/1951163a0. View

17.

Bachrach H . FOOT-AND-MOUTH DISEASE VIRUS: STRUCTURE AND MECHANISM OF DEGRADATION AS DEDUCED FROM ABSORBANCE-TEMPERATURE RELATIONSHIPS. J Mol Biol. 1964; 8:348-58. DOI: 10.1016/s0022-2836(64)80198-4. View

18.

Pringle C . INHIBITION OF MULTIPLICATION OF FOOT-AND-MOUTH DISEASE VIRUS BY GUANIDINE HYDROCHLORIDE. Nature. 1964; 204:1012-3. DOI: 10.1038/2041012a0. View

19.

Pringle C . EVIDENCE OF GENETIC RECOMBINATION IN FOOT-AND-MOUTH DISEASE VIRUS. Virology. 1965; 25:48-54. DOI: 10.1016/0042-6822(65)90250-3. View

20.

Mowat G, Chapman W . Growth of foot-and-mouth disease virus in a fibroblastic cell line derived from hamster kidneys. Nature. 1962; 194:253-5. DOI: 10.1038/194253a0. View