Alpha 2.0
Login Register
» Articles » PMID: 6284423

Cytomegalovirus Infection in Infancy: Virological and Immunological Studies

Overview
Journal Clin Exp Immunol
Publisher Oxford University Press
Specialty Allergy & Immunology
Date 1982 Jan 1
PMID 6284423
Citations 7
Authors
R C Gehrz
K M Linner
W R Christianson
A E Ohm
H H Balfour Jr
Affiliations
Soon will be listed here.
Abstract

Immunological and virological studies on 18 infants with cytomegalovirus (CMV) infection were performed. Eleven of these infants were studied on multiple occasions over a period of 1 year. The patients were divided into three clinical groups based on the probable time of infection and the resulting variation in clinical presentation. General parameters of cell-mediated immunity as determined by E-rosette formation and lymphocyte proliferative responses to mitogens and antigens were found to be normal. Quantitation of CMV excretion in urine, CMV-specific immunofluorescent (IF) and complement-fixing (CF) antibody titres and CMV-specific cell-mediated immune responses were done on all patients at approximately monthly intervals. Throughout the study period all patients continued to excrete CMV despite the presence of high antibody titres to the virus. CMV-specific lymphocyte proliferative responses were absent or diminished in 15 of the 18 patients. The immunological and virological status of all patients was similar regardless of the clinical manifestation of infection.

Citing Articles

Pediatric roots of cytomegalovirus recurrence and memory inflation in the elderly.

Adler S, Reddehase M Med Microbiol Immunol. 2019; 208(3-4):323-328.

PMID: 31062089 DOI: 10.1007/s00430-019-00609-6.

Longitudinal Kinetics of Cytomegalovirus-Specific T-Cell Immunity and Viral Replication in Infants With Congenital Cytomegalovirus Infection.

Chen S, Holmes T, Slifer T, Ramachandran V, Mackey S, Hebson C J Pediatric Infect Dis Soc. 2016; 5(1):14-20.

PMID: 26908487 PMC: 4765489. DOI: 10.1093/jpids/piu089.

Effects of interleukin-12 and interleukin-15 on measles-specific T-cell responses in vaccinated infants.

Gans H, Yasukawa L, Zhang C, Wakim R, Rinki M, DeHovitz R Viral Immunol. 2008; 21(2):163-72.

PMID: 18419254 PMC: 2599809. DOI: 10.1089/vim.2007.0113.

Cytomegalovirus (CMV): specific lymphokine production in congenital CMV infection.

Gehrz R, Leonard T Clin Exp Immunol. 1985; 62(3):507-14.

PMID: 3002688 PMC: 1577482.

Immune mechanisms in congenital cytomegalovirus infection: activation of CMV-specific T helper cells (CMV-Th) by exogenous IL-2.

Gehrz R, Peterson E, Liu Y Clin Exp Immunol. 1988; 74(3):333-8.

PMID: 2853015 PMC: 1542040.

References
1.
Hanshaw J . Congenital cytomegalovirus infection: a fifteen year perspective. J Infect Dis. 1971; 123(5):555-61. DOI: 10.1093/infdis/123.5.555. View
2.
Fleisher T, Luckasen J, Sabad A, Gehrtz R, Kersey J . T and B lymphocyte subpopulations in children. Pediatrics. 1975; 55(2):162-5. View
3.
Rola-Pleszczynski M, Frenkel L, FUCCILLO D, Hensen S, VINCENT M, Reynolds D . Specific impairment of cell-mediated immunity in mothers of infants with congenital infection due to cytomegalovirus. J Infect Dis. 1977; 135(3):386-91. DOI: 10.1093/infdis/135.3.386. View
4.
Rinaldo Jr C, Black P, Hirsch M . Interaction of cytomegalovirus with leukocytes from patients with mononucleosis due to cytomegalovirus. J Infect Dis. 1977; 136(5):667-78. DOI: 10.1093/infdis/136.5.667. View
5.
Gehrz R, Marker S, Knorr S, Kalis J, Balfour Jr H . Specific cell-mediated immune defect in active cytomegalovirus infection of young children and their mothers. Lancet. 1977; 2(8043):844-7. DOI: 10.1016/s0140-6736(77)90782-6. View