Postsynaptic Inhibitory Effects of Met- and Leu-enkephalin on Endocrine and Adjacent Neurones in the Preoptic-septal Region of the Guinea Pig

Overview

Journal Regul Pept

Specialty Biochemistry

Date 1982 Feb 1

PMID 6278541

Citations 4

Authors

B Carette

P Poulain

Affiliations

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Abstract

Iontophoretic application of enkephalins induced inhibitory effects on unit activity of endocrine and adjacent neurones in the preoptic-septal region. Antagonism or lack of antagonism of these effects by naloxone indicated an action of enkephalins through different opiate receptors. Inhibitory effects of enkephalins were obtained during iontophoretic application of Mg2+, showing that these opioid peptides acted postsynaptically. Because enkephalin acts on endocrine neurones, these opioid peptides might be involved in the control of gonadotrophic hormone release by acting on cell bodies of LH-RH neurones.

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