The Effect of Autonomic Drugs on Ureteric Peristalsis: a Canine in Vivo Study

Overview

Journal Urol Res

Specialty Urology

Date 1981 Jan 1

PMID 6272463

Authors

M E Mayo

S A Halbert

Affiliations

Soon will be listed here.

Abstract

An in vivo canine model was developed in which the renal pelvis was perfused by a cannula nephrostomy and ureteric activity assessed by monitoring bolus volume and interperistaltic interval. The effect of autonomic drugs showed that the ureter contained alpha-adrenergic receptors which on stimulation caused an increase in ureteric contraction rate and a decrease in bolus volume. With beta-adrenergic receptor stimulation, there was complete inhibition of ureteric peristalsis for a variable period and evidence is presented that the beta-adrenergic receptors may be beta 1 rather than beta 2. Cholinergic stimulation of ureteric rate was observed, but seemed to be mediated indirectly via alpha-adrenergic receptors. No significant change was seen in ureteric activity with adrenergic blocking agents alone, suggesting that the physiological importance of these receptors in normal activity is questionable.

References

Longrigg N . Minor calyces as primary pacemaker sites for ureteral activity in man. Lancet. 1975; 1(7901):253-4. DOI: 10.1016/s0140-6736(75)91145-9. View

Dale R, Constantinou C, BRIGGS E, GOVAN D . Dynamics of the upper urinary tract. The effects of an indwelling ureteral catheter on ureteral peristalsis. Invest Urol. 1971; 8(6):655-72. View

Gosling J, Dixon J . Species variation in the location of upper urinary tract pacemaker cells. Invest Urol. 1974; 11(5):418-23. View

Rose J, GILLENWATER J, ATTINGER F, Sim P, Wyker A . Ureteral wall tension. A new means of evaluating ureteral function. Invest Urol. 1973; 10(6):480-5. View

Weinberg S . Ureteral function. II. The ureteral catheter and the urometrogram. Invest Urol. 1975; 12(4):255-61. View

Reid R, Herman R, Teng C . Attempts at altering ureteral activity in the unanesthetized, conditioned dog with commonly employed drugs. Invest Urol. 1974; 12(1):74-8. View

AMBACHE N, Perry W, Robertson P . The effect of muscarine on perfused superior cervical ganglia of cats. Br J Pharmacol Chemother. 1956; 11(4):442-8. PMC: 1510566. DOI: 10.1111/j.1476-5381.1956.tb00014.x. View

Weinberg S . Ureteral function. III. The catheter and the geometry of the ureter. Invest Urol. 1976; 13(5):339-45. View

Long S, Nergardh A . Autonomic receptor functions of the human ureter: an in vitro study. Scand J Urol Nephrol. 1978; 12(1):23-6. View

10.

Constantinou C, Hrynczuk J . Urodynamics of the upper urinary tract. Invest Urol. 1976; 14(3):233-40. View

11.

STRUTHERS N . An experimental model for evaluating drug effects on the ureter. Br J Urol. 1973; 45(1):23-7. View

12.

BOATMAN D, Lewin M, Culp D, FLOCKS R . Pharmacologic evaluation of ureteral smooth muscle. A technique for monitoring ureteral peristalsis. Invest Urol. 1967; 4(6):509-20. View

13.

Wendel R, King L . The effect of a nonobstructing aperistaltic ureteral segment on renal function in the dog. Invest Urol. 1972; 9(5):365-8. View

14.

Malin Jr J, Deane R, BOYARSKY S . Characterisation of adrenergic receptors in human ureter. Br J Urol. 1970; 42(2):171-4. DOI: 10.1111/j.1464-410x.1970.tb10018.x. View

15.

Levy B, Wilkenfeld B . An analysis of selective beta receptor blockade. Eur J Pharmacol. 1969; 5(3):227-34. DOI: 10.1016/0014-2999(69)90142-3. View

16.

BRIGGS E, Constantinou C, GOVAN D . Dynamics of the upper urinary tract. The relationship of urine flow rate and rate of ureteral peristalsis. Invest Urol. 1972; 10(1):56-62. View

17.

OCONOR Jr V, DAWSON-EDWARDS P . Role of ureter in renal transplantation: I. Studies of denervated ureter with particular reference to ureteroureteral anastomosis. J Urol. 1959; 82:566-72. DOI: 10.1016/S0022-5347(17)65933-0. View

18.

Gosling J, Dixon J . Morphologic evidence that rhe renal calyx and pelvis control ureteric activity in the rabbit. Am J Anat. 1971; 130(4):393-408. DOI: 10.1002/aja.1001300403. View

19.

Weiss R . Clinical implications of ureteral physiology. J Urol. 1979; 121(4):401-13. DOI: 10.1016/s0022-5347(17)56799-3. View

20.

Rose J, GILLENWATER J . The effect of adrenergic and cholinergic agents and their blockers upon ureteral activity. Invest Urol. 1974; 11(6):439-51. View