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Theoretical Aspects of Translocation on DNA: Adenosine Triphosphatases and Treadmilling Binding Proteins

Overview
Journal Proc Natl Acad Sci U S A
Specialty Science
Date 1981 Aug 1
PMID 6272273
Citations 3
Authors
T L Hill
T Tsuchiya
Affiliations
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Abstract

The basic kinetic and bioenergetic theory is outlined for two kinds of translocation on DNA: (i) helicases that use ATP to move along single-stranded DNA or to move on and invade double-stranded DNA at a replication fork; and (ii) DNA-binding proteins (not ATPases) that form bound aggregates on single-stranded DNA and facilitate replication by steady-state treadmilling of molecules between the ends of the aggregate. The respective resemblances to myosin--actin in muscle and to steady-state treadmilling in solution of actin or tubulin are pointed out.

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References
1.
HUXLEY A, Simmons R . Proposed mechanism of force generation in striated muscle. Nature. 1971; 233(5321):533-8. DOI: 10.1038/233533a0. View
2.
Wegner A . Head to tail polymerization of actin. J Mol Biol. 1976; 108(1):139-50. DOI: 10.1016/s0022-2836(76)80100-3. View
3.
Margolis R, Wilson L . Addition of colchicine--tubulin complex to microtubule ends: the mechanism of substoichiometric colchicine poisoning. Proc Natl Acad Sci U S A. 1977; 74(8):3466-70. PMC: 431611. DOI: 10.1073/pnas.74.8.3466. View
4.
Yarranton G, Gefter M . Enzyme-catalyzed DNA unwinding: studies on Escherichia coli rep protein. Proc Natl Acad Sci U S A. 1979; 76(4):1658-62. PMC: 383449. DOI: 10.1073/pnas.76.4.1658. View
5.
Eisenberg E, Hill T, Chen Y . Cross-bridge model of muscle contraction. Quantitative analysis. Biophys J. 1980; 29(2):195-227. PMC: 1328691. DOI: 10.1016/S0006-3495(80)85126-5. View