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Nucleotide Sequence Changes in Polyoma Ts-a Mutants: Correlation with Protein Structure

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Journal J Virol
Date 1981 Mar 1
PMID 6262533
Citations 7
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Abstract

The mutations in three polyoma ts-a mutants have been determined. Two mutants, ts-25 and ts-52, have different single-base changes at the same position (2883) in the early region corresponding to a conserved glycine residue very near the C-terminus of the polyoma large T antigen. Mutant ts-48 has a single-base change at position 2341, as well as a second change at position 1228, in the region of large T antigen shared with medium T antigen.

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References
1.
Clewell D, Helinski D . Supercoiled circular DNA-protein complex in Escherichia coli: purification and induced conversion to an opern circular DNA form. Proc Natl Acad Sci U S A. 1969; 62(4):1159-66. PMC: 223628. DOI: 10.1073/pnas.62.4.1159. View

2.
Tjian R . The binding site on SV40 DNA for a T antigen-related protein. Cell. 1978; 13(1):165-79. DOI: 10.1016/0092-8674(78)90147-2. View

3.
Eckhart W . Properties of temperature-sensitive mutants of polyoma virus. Cold Spring Harb Symp Quant Biol. 1975; 39 Pt 1:37-40. DOI: 10.1101/sqb.1974.039.01.007. View

4.
Enea V, VOVIS G, Zinder N . Genetic studies with heteroduplex DNA of bacteriophage fl. Asymmetric segregation, base correction and implications for the mechanism of genetic recombination. J Mol Biol. 1975; 96(3):495-509. DOI: 10.1016/0022-2836(75)90175-8. View

5.
Grunstein M, Hogness D . Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. Proc Natl Acad Sci U S A. 1975; 72(10):3961-5. PMC: 433117. DOI: 10.1073/pnas.72.10.3961. View