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Genomic Integration of Bovine Leukemia Provirus: Comparison of Persistent Lymphocytosis with Lymph Node Tumor Form of Enzootic

Overview
Journal Proc Natl Acad Sci U S A
Specialty Science
Date 1980 May 1
PMID 6248854
Citations 40
Authors
R Kettmann
Y Cleuter
M MAMMERICKX
G Bernardi
A Burny
H CHANTRENNE
Affiliations
Soon will be listed here.
Abstract

Integration of bovine leukemia proviral DNA in the genome of infected cells was investigated in cattle affected by either the persistent lymphocytosis or the lymph node tumor form of enzootic bovine leukosis. In persistent lymphocytosis, proviral DNA was found to be integrated at a large number of genomic sites in one-fourth to one-third of circulating leukocytes. In the lymph node tumor form, in contrast, proviral DNA was found to be integrated at one or very few sites in the genomes of a larger fraction of both circulating leukocytes and lymph node tumor cells.

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