Electron Spin Resonance Studies on Caeruloplasmin and Iron Transferrin in Patients with Chronic Lymphocytic Leukaemia

Overview

Journal Br J Cancer

Specialty Oncology

Date 1980 Mar 1

PMID 6248093

Citations 1

Authors

J A Green

T Pocklington

A A Dawson

M Foster

Affiliations

Soon will be listed here.

Abstract

Whole-blood caeruloplasmin measured by electron spin resonance was studied in 41 patients with chronic lymphocytic leukaemia. The levels were above normal at all stages of the disease, rose with increasing clinical involvement, and were higher in progressive than inactive disease. Whole-blood iron transferrin levels were more variable, and were significantly raised only in patients with marrow failure.

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References

HRGOVCIC M, Tessmer C, Minckler T, Mosier B, TAYLOR G . Serum copper levels in lymphoma and leukemia. Special reference to Hodgkin's disease. Cancer. 1968; 21(4):743-55. DOI: 10.1002/1097-0142(196804)21:4<743::aid-cncr2820210427>3.0.co;2-a. View

Jaffe N, Bishop J . The serum iron level, hematocrit, sedimentation rate, and leukocyte alkaline phosphatase level in pediatric patients with Hodgkin's disease. Cancer. 1970; 26(2):332-7. DOI: 10.1002/1097-0142(197008)26:2<332::aid-cncr2820260214>3.0.co;2-j. View

Tessmer C, HRGOVCIC M, BROWN B, Wilbur J, Thomas F . Serum copper correlations with bone marrow. Cancer. 1972; 29(1):173-9. DOI: 10.1002/1097-0142(197201)29:1<173::aid-cncr2820290127>3.0.co;2-1. View

Beamish M, Jones P, Trevett D, Evans I, Jacobs A . Iron metabolism in Hodgkin's disease. Br J Cancer. 1972; 26(6):444-52. PMC: 2008667. DOI: 10.1038/bjc.1972.61. View

Frieden E . The ferrous to ferric cycles in iron metabolism. Nutr Rev. 1973; 31(2):41-4. DOI: 10.1111/j.1753-4887.1973.tb05977.x. View

HRGOVCIC M, Tessmer C, Thomas F, Fuller L, Gamble J, SHULLENBERGER C . Significance of serum copper levels in adult patients with Hodgkin's disease. Cancer. 1973; 31(6):1337-45. DOI: 10.1002/1097-0142(197306)31:6<1337::aid-cncr2820310606>3.0.co;2-w. View

Ray G, Wolf P, Kaplan H . Value of laboratory indicators in Hodgkin's disease: preliminary results. Natl Cancer Inst Monogr. 1973; 36:315-23. View

Foster M, Pocklington T, Miller J, MALLARD J . A study of electron spin resonance spectra of whole blood from normal and tumour bearing patients. Br J Cancer. 1973; 28(4):340-8. PMC: 2008905. DOI: 10.1038/bjc.1973.157. View

Rai K, SAWITSKY A, CRONKITE E, CHANANA A, Levy R, Pasternack B . Clinical staging of chronic lymphocytic leukemia. Blood. 1975; 46(2):219-34. View

10.

Foster M, Dawson A, Pockington T, Fell L . Electron spin resonance measurements of blood caeruloplasmin and iron transferrin levels in patients with non-Hodgkin's lymphoma. Clin Radiol. 1977; 28(1):23-8. DOI: 10.1016/s0009-9260(77)80131-1. View

11.

Pocklington T, Foster M . Electron spin resonance of caeruloplasmin and iron transferrin in blood of patients with various malignant diseases. Br J Cancer. 1977; 36(3):369-74. PMC: 2025408. DOI: 10.1038/bjc.1977.202. View

12.

Fisher G, Shifrine M . Hypothesis for the mechanism of elevated serum copper in cancer patients. Oncology. 1978; 35(1):22-5. DOI: 10.1159/000225249. View

13.

ANDREWS G . Studies of plasma zinc, copper, caeruloplasmin, and growth hormone: with special reference to carcinoma of the bronchus. J Clin Pathol. 1979; 32(4):325-33. PMC: 1145668. DOI: 10.1136/jcp.32.4.325. View

14.

LAHEY M, GUBLER C, CARTWRIGHT G, Wintrobe M . Studies on copper metabolism. VII. Blood copper in pregnancy and various pathologic states. J Clin Invest. 1953; 32(4):329-39. PMC: 438346. DOI: 10.1172/JCI102743. View

15.

Markowitz H, GUBLER C, MAHONEY J, CARTWRIGHT G, Wintrobe M . Studies on copper metabolism. XIV. Copper, ceruloplasmin and oxidase activity in sera of normal human subjects, pregnant women, and patients with infection, hepatolenticular degeneration and the nephrotic syndrome. J Clin Invest. 1955; 34(10):1498-508. PMC: 438726. DOI: 10.1172/JCI103201. View