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Variation in the Susceptibility of BHK Populations and Cloned Cell Lines to Three Strains of Foot-and-mouth Disease Virus

Overview
Journal Arch Virol
Specialty Microbiology
Date 1980 Jan 1
PMID 6245630
Citations 9
Authors
J B Clarke
R E Spier
Affiliations
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Abstract

BHK monolayer and suspension cell populations maintained in different laboratories were found to vary in their susceptibility to infection with three strains of foot-and-mouth disease virus (FMDV). The susceptibility of parent cell populations was compared with that of individual clones of cells derived from them. The populations tested in this way consisted of a number of cell types, each expressing a different capacity to produce FMDV. The relative numbers of susceptible and insusceptible cells in each population appeared to determine the overall susceptibility of that population. The ability of the FMDV strain Asia 1 Iran 1/73 to multiply was an indicator of the general FMDV susceptibility of a BHK cell population.

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References
1.
Bolt K, Clarke J, Spier R . The use of frozen BHK21 C13 cells to control the biological parameters for cell and foot-and-mouth disease virus growth. Dev Biol Stand. 1979; 42:47-53. View
2.
Macpherson I, Stoker M . Polyoma transformation of hamster cell clones--an investigation of genetic factors affecting cell competence. Virology. 1962; 16:147-51. DOI: 10.1016/0042-6822(62)90290-8. View
3.
Mowat G, Chapman W . Growth of foot-and-mouth disease virus in a fibroblastic cell line derived from hamster kidneys. Nature. 1962; 194:253-5. DOI: 10.1038/194253a0. View
4.
Barteling S . The use of frozen cells in the agar-cell suspension titration technique. A reproducible system. Brief report. Arch Gesamte Virusforsch. 1972; 38(2):271-3. DOI: 10.1007/BF01249678. View
5.
Meloen R . Localisation on foot-and-mouth disease virus (FMDV) of an antigenic deficiency induced by passage in BHK cells. Arch Virol. 1976; 51(4):299-306. DOI: 10.1007/BF01317933. View