Tumor-promoting Phorbol Esters Stimulate Hematopoietic Colony Formation in Vitro

Overview

Journal Science

Specialty Science

Date 1980 Apr 25

PMID 6245446

Citations 12

Authors

R K Stuart

J A Hamilton

Affiliations

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Abstract

Tumor-promoting phorbol esters stimulated mouse bone marrow cells to form myeloid colonies in agar cultures without added colony-stimulating factors. The colony-stimulating ability of various phorbol esters correlated well with their ability to promote skin tumors in vivo. These results suggest that phorbol esters mimic the action of specific colony-stimulating factors that regulate growth.

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