Haemodynamic Effects of Beta-adrenorecptor Blockers in Hypertension

Overview

Journal Drugs

Specialty Pharmacology

Date 1976 Jan 1

PMID 6245

Citations 4

Authors

B Ablad

B LJUNG

R SANNERSTEDT

Affiliations

Soon will be listed here.

Abstract

The haemodynamic effect pattern of beta-blockers in hypertension is discussed. The time curve of the antihypertensive effect differs from that of cardiac beta-blockade. The antihypertensive effect is characterized by a slower onset at the start of treatment and a more gradual disappearance when therapy is withdrawn. It appears that the crucial effect of beta-blockers in hypertension is a gradually developing reduction in total peripheral vascular resistance. The mechanism of this apparent vasodilator action is unknown. Various possible factors involved are mentioned. One is a reduced efficiency of transmitter release from the peripheral adrenergic neuron. Such an action may contribute to the antihypertensive effect, as judged by results of animal experiments described.

Citing Articles

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KUBIK M, Coote J Eur J Clin Pharmacol. 1984; 26(1):1-6.

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Double-blind comparison of metoprolol, alprenolol, and oxprenolol in hypertension.

Tuomilehto J, Nissinen A Eur J Clin Pharmacol. 1979; 16(6):369-74.

PMID: 393518 DOI: 10.1007/BF00568195.

Effects of propranolol and metoprolol on haemodynamic and respiratory indices and on perceived exertion during exercise in hypertensive patients.

van Herwaarden C, Binkhorst R, Fennis J, vant Laar A Br Heart J. 1979; 41(1):99-105.

PMID: 371643 PMC: 482016. DOI: 10.1136/hrt.41.1.99.

Acebutolol in hypertension--double-blind trial against placebo.

Martin M, Phillips C, Smith A Br J Clin Pharmacol. 1978; 6(4):351-6.

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