The Effect of Acute Zimeldine and Alaproclate Administration on the Acquisition of Two-way Active Avoidance: Comparison with Other Antidepressant Agents, Test of Selectivity and Sub-chronic Studies

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1984 Jan 1

PMID 6239299

Citations 3

Authors

T Archer

S O Ogren

G Johansson

S B Ross

Affiliations

Soon will be listed here.

Abstract

The dose-dependent effect of acute zimeldine and alaproclate treatment upon the acquisition of two-way and one-way active avoidance in the rat was studied in a single-session and in a repeated-sessions design. Zimeldine (5-20 mg/kg, IP), but not alaproclate, caused disruptions of two-way avoidance acquisition. Acquisition deficits were also caused by citalopram and fluoxetine but not the other antidepressant drugs tested. Zimeldine, but not alaproclate or desipramine, caused a slight but non-significant impairment of one-way active avoidance; neither zimeldine nor alaproclate produced any effects upon fear conditioning and retention testing. The long-term action of p-chloroamphetamine (2 X 10 mg/kg) antagonised the acute zimeldine effect totally, and chronic treatment with zimeldine (15 days, 1 X 50 mumol/kg) and chlorimipramine (15 days, 2 X 10 mumol/kg) also caused some partial blockade of the two-way avoidance deficit. These data seem to suggest some involvement of serotonin (5-HT) in the observed disruptions of two-way active avoidance caused by acute zimeldine treatment.

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