Interaction of Mycoplasmas and Phagocytes

Overview

Journal Yale J Biol Med

Specialty Biology

Date 1983 Sep 1

PMID 6236619

Citations 10

Authors

C J Howard

G Taylor

Affiliations

Soon will be listed here.

Abstract

Aspects of the interaction of certain mycoplasmas with macrophages and neutrophils in vivo and in vitro have been studied using two systems, one involving M. pulmonis in mice and the other involving M. bovis with bovine leucocytes. Studies with M. pulmonis indicated that the disappearance of viable organisms from the peritoneal cavity was not enhanced in SPF mice in which a peritoneal exudate rich in neutrophils had been induced. However, viable M. pulmonis organisms disappeared more rapidly from the peritoneal cavities with exudates containing increased numbers of macrophages. Experiments in vitro studied the opsonic effect of bovine IgG isotypes for bovine neutrophils and alveolar macrophages. Both IgG1 and IgG2 promoted killing of M. bovis by alveolar macrophages but IgG2 was more effective than IgG1 at promoting mycoplasma killing by neutrophils. Further studies in vitro indicated that certain bovine mycoplasma could inhibit killing of Escherichia coli by bovine neutrophils.

Citing Articles

mastitis in dairy cattle.

Gelgie A, Desai S, Gelalcha B, Kerro Dego O Front Vet Sci. 2024; 11:1322267.

PMID: 38515536 PMC: 10956102. DOI: 10.3389/fvets.2024.1322267.

Eating the Enemy: Mycoplasma Strategies to Evade Neutrophil Extracellular Traps (NETs) Promoting Bacterial Nucleotides Uptake and Inflammatory Damage.

Cacciotto C, Alberti A Int J Mol Sci. 2022; 23(23).

PMID: 36499356 PMC: 9740415. DOI: 10.3390/ijms232315030.

downregulates RECK to promote matrix metalloproteinase-9 secretion by bronchial epithelial cells.

Qin L, Liu L, Wu Y, Chen Y, Wu Y, Luo H Virulence. 2022; 13(1):1270-1284.

PMID: 35892136 PMC: 9336473. DOI: 10.1080/21505594.2022.2101746.

Immune Evasion of .

Askar H, Chen S, Hao H, Yan X, Ma L, Liu Y Pathogens. 2021; 10(3).

PMID: 33806506 PMC: 7998117. DOI: 10.3390/pathogens10030297.

Subversion of the Immune Response by Human Pathogenic Mycoplasmas.

Qin L, Chen Y, You X Front Microbiol. 2019; 10:1934.

PMID: 31497004 PMC: 6712165. DOI: 10.3389/fmicb.2019.01934.

References

Simberkoff M, Elsbach P . The interaction in vitro between polymorphonuclear leukocytes and mycoplasma. J Exp Med. 1971; 134(6):1417-30. PMC: 2139108. DOI: 10.1084/jem.134.6.1417. View

McGuire T, Musoke A, Kurtti T . Functional properties of bovine IgG1 and IgG2: interaction with complement, macrophages, neutrophils and skin. Immunology. 1979; 38(2):249-56. PMC: 1457935. View

Brownlie J, Howard C, GOURLAY R . The effect of an intramammary infusion of endotoxin on experimentally induced mycoplasmal mastitis. J Hyg (Lond). 1979; 83(3):501-5. PMC: 2130171. DOI: 10.1017/s0022172400026346. View

Taylor G, Howard C . Interaction of Mycoplasma pulmonis with mouse peritoneal macrophages and polymorphonuclear leucocytes. J Med Microbiol. 1980; 13(1):19-30. DOI: 10.1099/00222615-13-1-19. View

Howard C, Taylor G . Variation in the virulence of strains of Mycoplasma pulmonis related to susceptibility to killing by macrophages in vivo. J Gen Microbiol. 1979; 114(2):289-94. DOI: 10.1099/00221287-114-2-289. View

Taylor G, Howard C . Class-specific antibody responses to Mycoplasma pulmonis in sera and lungs of infected and vaccinated mice. Infect Immun. 1980; 29(3):1160-8. PMC: 551253. DOI: 10.1128/iai.29.3.1160-1168.1980. View

Howard C, Taylor G, Brownlie J . Surface receptors for immunoglobulin on bovine polymorphonuclear neutrophils and macrophages. Res Vet Sci. 1980; 29(1):128-30. View

Davis J, Delozier K, Asa D, Minion F, Cassell G . Interactions between murine alveolar macrophages and Mycoplasma pulmonis in vitro. Infect Immun. 1980; 29(2):590-9. PMC: 551163. DOI: 10.1128/iai.29.2.590-599.1980. View

Taylor G, Howard C . Protection of mice against Mycoplasma pulmonis infection using purified mouse immunoglobulins: comparison between protective effect and biological properties of immunoglobulin classes. Immunology. 1981; 43(3):519-25. PMC: 1555062. View

10.

Mossmann H, Schmitz B, Possart P, Hammer D . Antibody-dependent, cell-mediated cytotoxicity in cattle: transfer of IgG subclasses in relation to the protection of the newborn calf. Adv Exp Med Biol. 1981; 137:279-92. View

11.

Carlson G, Kaneko J . Isolation of leukocytes from bovine peripheral blood. Proc Soc Exp Biol Med. 1973; 142(3):853-6. DOI: 10.3181/00379727-142-37131. View

12.

Cole B, WARD J . Interaction of Mycoplasma arthritidis and other mycoplasmas with murine peritoneal macrophages. Infect Immun. 1973; 7(5):691-9. PMC: 422746. DOI: 10.1128/iai.7.5.691-699.1973. View

13.

Fey H, Pfister H, Messerli J, Sturzenegger N, Grolimund F . Methods of isolation, purification and quantitation of bovine immunoglobulins: a technical review. Zentralbl Veterinarmed B. 1976; 23(4):269-300. DOI: 10.1111/j.1439-0450.1976.tb00682.x. View

14.

Howard C, Taylor G, Collins J, GOURLAY R . Interaction of Mycoplasma dispar and Mycoplasma agalactiae subsp. bovis with bovine alveolar macrophages and bovine lacteal polymorphonuclear leukocytes. Infect Immun. 1976; 14(1):11-7. PMC: 420837. DOI: 10.1128/iai.14.1.11-17.1976. View

15.

Jones T, Hirsch J . The interaction in vitro of Mycoplasma pulmonis with mouse peritoneal macrophages and L-cells. J Exp Med. 1971; 133(2):231-59. PMC: 2138893. DOI: 10.1084/jem.133.2.231. View