Autoradiographic Evidence for the Heterogeneity of 5-HT1 Sites in the Rat Brain

Overview

Journal Brain Res

Specialty Neurology

Date 1984 Jan 16

PMID 6230136

Citations 30

Authors

M Marcinkiewicz

D Verge

H Gozlan

L PICHAT

M Hamon

Affiliations

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Abstract

The distribution of the binding sites of a new, potent agonist of serotonin (5-HT), 8-OH-N,N-dipropyl-2-aminotetralin (PAT), was studied in the rat brain with the quantitative autoradiographic technique utilizing tritium-sensitive LKB film. The localization of [3H]PAT binding sites was very similar to that of [3H]5-HT binding sites, except in some discrete regions (choroid plexus, striatum, area preoptica lateralis, subiculum, and substantia nigra), which exhibited very low levels of labeling with [3H]PAT and high levels with [3H]5-HT. These results indicate that 5-HT1 receptors are heterogeneous, and that [3H]PAT recognizes only a 5-HT1 subclass (called 5-HT1A).

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