Studies on Immunoregulatory Mechanisms in Acute and Chronic Hepatitis B

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1983 May 1

PMID 6222854

Citations 8

Authors

G Lemm

K Salzer

H WARNATZ

Affiliations

Soon will be listed here.

Abstract

Patients with acute hepatitis B and HBV-induced chronic hepatitis as well as normal control persons participated in the study. Hepatitis patients of both groups have decreased OKT4+/OKT8+T cell ratios due to an percental increase of OKT8+T cells in peripheral blood compared to the data of controls. Lymphocyte cultures of chronic hepatitis patients show reduced DNA synthesis after stimulation by allogeneic non-T cells, PHA, Con A and PWM. PWM-induced immunoglobulin secretion by B cells, determined by means of a reverse haemolytic plaque assay (RHPA) and a solid phase ELISA, showed comparable results in hepatitis B patients and controls. The AMLR, which is thought to reflect an autologous immunoregulatory phenomenon, is slightly impaired in cultures of hepatitis B patients in comparison to controls. Con A-induced suppressor cell activity on T cell reactions is decreased in hepatitis, whereas suppressor cell activity on B cell activation is within the same range as in cultures of controls. It is concluded from these data, that suppressor cell activity on T cell function is impaired in hepatitis B, whereas B cell functions and suppressor cell activity on B cell function are in the normal range. The results with the functional assays and the finding of increased proportions of OKT8+T cells in hepatitis B are considered to reflect properties of different T cell subpopulations, responsible for different immunoregulatory functions.

Citing Articles

Delayed type hypersensitivity (DTH) skin reaction to hepatitis B surface antigen (HBsAg) in patients with type B acute and chronic hepatitis.

Nagafuchi S, Kashiwagi S, Hayashi S, Inoue T, Imayama S, Takeshita M Clin Exp Immunol. 1985; 61(3):569-76.

PMID: 4075587 PMC: 1577265.

Immunoregulation of the in vitro anti-HBs antibody synthesis in chronic HBsAg carriers and in recently boosted anti-hepatitis B vaccine recipients.

Barnaba V, Valesini G, Levrero M, Zaccari C, VAN DYKE A, Falco M Clin Exp Immunol. 1985; 60(2):259-66.

PMID: 3874020 PMC: 1577043.

Circulating activated B cells in primary biliary cirrhosis.

James S, Jones E, Hoofnagle J, Strober W J Clin Immunol. 1985; 5(4):254-60.

PMID: 2995432 DOI: 10.1007/BF00929460.

Non-responsiveness to hepatitis-B vaccination: revaccination and immunogenetic typing.

Kramer A, HERTH D, von Keyserlingk H, Ludwig W, Hampl H, Sommer D Klin Wochenschr. 1988; 66(15):670-4.

PMID: 2971838 DOI: 10.1007/BF01726924.

The relationship between T cell subsets and T suppressor cell function in hepatitis B.

Liu F, Song P, Hao L J Tongji Med Univ. 1987; 7(2):111-6.

PMID: 2958640 DOI: 10.1007/BF02888172.

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