Chemotactic Efficiency of Various Chemoattractants for Polymorphonuclear Leukocytes in Inflammatory Acne Vulgaris

Overview

Journal Arch Dermatol Res

Specialty Dermatology

Date 1982 Jan 1

PMID 6219635

Citations 3

Authors

J Knop

T Bossecker

P M Kovary

Affiliations

Soon will be listed here.

Abstract

The chemoattractant efficiencies of a Propionibacterium acnes (P. acnes) cell wall preparation, a P. acnes culture supernatant, and a soluble comedonal extract in the presence and absence of autologous serum for polymorphonuclear leukocytes (PMNs) have been compared in the present study. It has been found that all three preparations have no or very little chemotactic activity for PMNs in the absence of serum. In the presence of autologous serum chemotactic factors is generated by all preparations via the alternative complement pathway. The relative efficiencies of the various preparations to induce chemotactic factor by the alternate complement pathway has been evaluated. Based on the bacterial numbers of the original preparations from which the test preparations had been derived the comedonal extract appears to be more efficient in generating chemotactic factor than the other preparations. It is concluded that in vivo generation of chemotactic factors occurs mainly via the alternate complement pathway activated by soluble comedonal factors diffusing through the follicular wall.

Citing Articles

Current concepts of the pathogenesis of acne: implications for drug treatment.

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Leukocyte chemotactic properties of soluble horny contents in epidermal cysts.

Takematsu H, Terui T, Torinuki W, Tagami H Arch Dermatol Res. 1987; 279(7):449-53.

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Analysis of the proinflammatory property of epidermal cyst contents: chemotactic C5a anaphylatoxin generation.

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