Flushing in Rosacea: a Possible Mechanism

Overview

Journal Arch Dermatol Res

Specialty Dermatology

Date 1982 Jan 1

PMID 6219630

Citations 7

Authors

M Guarrera

A Parodi

C Cipriani

C Divano

A Rebora

Affiliations

Soon will be listed here.

Abstract

Flushing in rosacea has been investigated by means of (a) pharmacological inhibition of some possible chemical mediators and (b) titration of bradykinin as a possible effector directly in the blood. Clonidine-inhibited flushing was seen in all patients (mean 45%), other drugs had poorer results. Bradykinin increased in all patients at the climax of flushing (mean 60%). These findings support the hypothesis that epinephrine promotes a bradykinin release responsible for vasodilation.

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