Quantitative and Functional Deficit of Suppressor T Cells in Children with Atopic Eczema

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1982 Oct 1

PMID 6217005

Citations 8

Authors

M Butler

D Atherton

R J Levinsky

Affiliations

Soon will be listed here.

Abstract

Helper (OKT4+) and suppressor (OKT8+) T cells were enumerated in 16 children with severe atopic eczema. Compared to controls (median 1 . 8) the ratio of OKT4+/OKT8+ cells in the patients was significantly higher (median 2 . 65, P less than 0 . 002). Functional suppressor activity in these patients was assessed by concanavalin A (Con A) activation and suppression of pokeweed mitogen (PWM) induced immunoglobulin production by plasma cells and Con A proliferation of T cells. In both assays a lack of suppression was shown (Con A/PWM, P less than 0 . 02; Con A/Con A, P less than 0 . 05). There was a significant inverse correlation between the helper/suppressor ratio and functional suppressor activity (P less than 0 . 01). These results indicate that a defect of T cell regulation does exist in atopic eczema and if it is of primary pathogenic importance, immunotherapy to restore the balance may prove useful.

Citing Articles

Atopic allergy in relation to cell-mediated immunity.

Bjorksten B Clin Rev Allergy. 1984; 2(2):95-106.

PMID: 6375851

Basophils in human disease.

Mitchell E, Askenase P Clin Rev Allergy. 1983; 1(3):427-48.

PMID: 6370410 DOI: 10.1007/BF02991231.

Pathogenesis of Mooren's ulcer: some new concepts.

Murray P, Rahi A Br J Ophthalmol. 1984; 68(3):182-7.

PMID: 6230102 PMC: 1040283. DOI: 10.1136/bjo.68.3.182.

Control of IgE synthesis in man.

Leung D, Geha R J Clin Immunol. 1986; 6(4):273-83.

PMID: 2943758 DOI: 10.1007/BF00917327.

Immunoregulatory abnormalities in atopic dermatitis.

Leung D, Geha R Clin Rev Allergy. 1986; 4(1):67-86.

PMID: 2938710 DOI: 10.1007/BF02991188.

References

Tada T, Taniguchi M, Okumura K . Regulation of homocytotropic antibody formation in the rat. II. Effect of X-irradiation. J Immunol. 1971; 106(4):1012-8. View

Okumura K, Tada T . Regulation of homocytotropic antibody formation in the rat. 3. Effect of thymectomy and splenectomy. J Immunol. 1971; 106(4):1019-25. View

Taniguchi M, Tada T . Regulation of homocytotropic antibody formation in the rat. IV. Effects of various immunosuppressive drugs. J Immunol. 1971; 107(2):579-85. View

Okumura K, Tada T . Regulation of homocytotropic antibody formation in the rat. VI. Inhibitory effect of thymocytes on the homocytotropic antibody response. J Immunol. 1971; 107(6):1682-9. View

Katz D, Hamaoka T, Newburger P, Benacerraf B . Hapten-specific IgE antibody responses in mice. IV. Evidence for distinctive sensitivities of IgE and IgG B lymphocytes to the regulatory influence of T cells. J Immunol. 1974; 113(3):974-83. View

Taniguchi M, Tada T . Regulation of homocytotropic antibody formation in the rat. X. IgT-like molecule for the induction of homocytotropic antibody response. J Immunol. 1974; 113(6):1757-69. View

Shou L, Schwartz S, GOOD R . Suppressor cell activity after concanavalin A treatment of lymphocytes from normal donors. J Exp Med. 1976; 143(5):1100-10. PMC: 2190183. DOI: 10.1084/jem.143.5.1100. View

Takatsu K, Ishizaka K . Reaginic antibody formation in the mouse. VII. Induction of suppressor T cells for IgE and IgG antibody responses. J Immunol. 1976; 116(5):1257-64. View

Caplin J, Capriles A, STRAUB D, Neiburger J, Wilkinson J, Dockhorn R . Allergy in the Wiskott Aldrich syndrome: a case report. Ann Allergy. 1977; 39(1):43-4. View

10.

Strannegard O, Strannegard I, Juto P . Pathogenesis of atopic allergy. Lancet. 1978; 1(8060):385-6. DOI: 10.1016/s0140-6736(78)91106-6. View

11.

Pichler W, Lum L, Broder S . Fc-receptors on human T lymphocytes. I. Transition of Tgamma to Tmu cells. J Immunol. 1978; 121(4):1540-8. View

12.

Juto P, Strannegard O . T lymphocytes and blood eosinophils in early infancy in relation to heredity for allergy and type of feeding. J Allergy Clin Immunol. 1979; 64(1):38-42. DOI: 10.1016/0091-6749(79)90081-2. View

13.

Canonica G, Mingari M, Melioli G, Colombatti M, Moretta L . Imbalances of T cell subpopulations in patients with atopic diseases and effect of specific immunotherapy. J Immunol. 1979; 123(6):2669-72. View

14.

Martinez J, Santos J, Stechschulte D, Abdou N . Nonspecific suppressor cell function in atopic subjects. J Allergy Clin Immunol. 1979; 64(6 Pt 1):485-90. DOI: 10.1016/0091-6749(79)90057-5. View

15.

Reinherz E, Moretta L, Roper M, Breard J, Mingari M, Cooper M . Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison. J Exp Med. 1980; 151(4):969-74. PMC: 2185839. DOI: 10.1084/jem.151.4.969. View

16.

Stingl G, Gazze L, CZARNECKI N, Wolff K . T cell abnormalities in atopic dermatitis patients: imbalances in T cell subpopulations and impaired generation of Con A-induced suppressor cells. J Invest Dermatol. 1981; 76(6):468-73. DOI: 10.1111/1523-1747.ep12521135. View

17.

Siegel R, Issekutz T, Schwaber J, Rosen F, Geha R . Deficiency of T helper cells in transient hypogammaglobulinemia of infancy. N Engl J Med. 1981; 305(22):1307-13. DOI: 10.1056/NEJM198111263052202. View

18.

Layward L, Levinsky R, Butler M . Long-term abnormalities in T and B lymphocyte function in children following treatment for acute lymphoblastic leukaemia. Br J Haematol. 1981; 49(2):251-8. DOI: 10.1111/j.1365-2141.1981.tb07221.x. View

19.

Jensen J, Cramers M, Thestrup-Pedersen K . Subpopulations of T lymphocytes and non-specific suppressor cell activity in patients with atopic dermatitis. Clin Exp Immunol. 1981; 45(1):118-23. PMC: 1537246. View

20.

Leung D, Rhodes A, Geha R . Enumeration of T cell subsets in atopic dermatitis using monoclonal antibodies. J Allergy Clin Immunol. 1981; 67(6):450-5. DOI: 10.1016/0091-6749(81)90098-1. View