Alpha 2.0
Login Register
» Articles » PMID: 6215841

Comparison in Rats of the Anti-inflammatory and Gastric Irritant Effects of Etodolac with Several Clinically Effective Anti-inflammatory Drugs

Overview
Journal Agents Actions
Specialty Pharmacology
Date 1982 Jul 1
PMID 6215841
Citations 14
Authors
R R Martel
J Klicius
Affiliations
Soon will be listed here.
Abstract

The anti-inflammatory and gastric effects of etodolac were compared in the rat with those of seven clinically established nonsteroidal anti-inflammatory drugs. The anti-inflammatory potency of etodolac was found to lie between that of sulindac and piroxicam. Etodolac was 2.8 times more active than sulindac and 2.2 times less active than piroxicam. Compared to phenylbutazone it was 12.5 times more potent. The irritation produced on the gastric mucosa was less than that of sulindac, although this difference did not reach statistical significance. However, etodolac was significantly (p less than 0.05) less irritant than piroxicam. Of the drugs studied, etodolac showed the highest ratio between the irritant ED50 and the dose which inhibited inflammation by 50%. From these results etodolac is predicted to be a potent anti-inflammatory drug with a high gastric tolerance. Clinical trials appear to confirm these predictions.

Citing Articles

Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status.

Hemshekhar M, Thushara R, Jnaneshwari S, Devaraja S, Kemparaju K, Girish K Eur J Nutr. 2012; 52(7):1787-99.

PMID: 23269651 DOI: 10.1007/s00394-012-0482-6.

Predictability of the clinical potency of NSAIDs from the preclinical pharmacodynamics in rats.

Mukherjee A, Hale V, Borga O, Stein R Inflamm Res. 1996; 45(11):531-40.

PMID: 8951503 DOI: 10.1007/BF02342223.

Gastrointestinal irritancy, antiinflammatory activity, and prostanoid inhibition in the rat. Differentiation of effects between nabumetone and etodolac.

Melarange R, Gentry C, Durie M, OConnell C, Blower P Dig Dis Sci. 1994; 39(3):601-8.

PMID: 8131699 DOI: 10.1007/BF02088349.

Comparative effects of long term treatment with etodolac, naproxen and ibuprofen on articular and bone changes associated with adjuvant arthritis in rats.

Martel R, Klicius J, Metcalf G, Rona G Agents Actions. 1984; 15(3-4):403-12.

PMID: 6240930 DOI: 10.1007/BF01972379.

Comparative effects of etodolac, indomethacin, and benoxaprofen on icosanoid biosynthesis.

Sirois P, Saura C, Salari H, Borgeat P Inflammation. 1984; 8(4):353-64.

PMID: 6240459 DOI: 10.1007/BF00918212.

References
1.
Hall J, Hallett C . A simple precise method for measuring rodent paw volume. J Pharm Pharmacol. 1975; 27(8):623. DOI: 10.1111/j.2042-7158.1975.tb09521.x. View
2.
Martel R, Klicius J, Herr F . Investigation of 1,3,4,9-Tetrahydro-1-popylpyrano [3,4-b] indole-1-acetic acid (prodolic acid), a new non-steroidal anti-inflammatory agent, in rats. Agents Actions. 1974; 4(5):370-6. DOI: 10.1007/BF01964939. View
3.
Robinson W, Martel R, Ferdinandi E, Kraml M . Effect of ring substitution on the metabolic fate and anti-inflammatory activity of some prodolic acid analogs. J Pharmacol Exp Ther. 1977; 203(3):729-35. View
4.
Craig G, BUCHANAN W . Antirheumatic drugs: clinical pharmacology and therapeutic use. Drugs. 1980; 20(6):453-84. DOI: 10.2165/00003495-198020060-00002. View
5.
WAX J, Tessman D, WINDER C, Stephens M . A sensitive method for the comparative bioassay of nonsteroidal anti-inflammatory compounds in adjuvant-induced primary inflammation in the rat. J Pharmacol Exp Ther. 1975; 192(1):166-71. View