Immunoglobulin Production After Marrow Transplantation. III. The Functional Heterogeneity of FC-IgG Receptor Positive and Negative T Cell Subpopulations

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1982 Jun 1

PMID 6214343

Citations 3

Authors

L G Lum

M C Seigneuret

R C Ostenson

R Storb

Affiliations

Soon will be listed here.

Abstract

Ten patients with chronic graft-versus-host disease (GVHD) after HLA-identical marrow transplantation were studied between 372 and 1649 days post-transplant for their T cell subset functions in pokeweed mitogen-stimulated immunoglobulin (Ig) synthesis. In vitro Ig synthesis was assessed using an indirect haemolytic plaque assay after 6 days of culture. T cells, TG+ cells (Fc-IgG receptor positive), TG- cells (Fc-IgG receptor negative), and B cell-enriched populations from the patients were co-cultured with normal T and/or B cells. Such cultures in patients with chronic GVHD showed deficient B cell activity (eight of 10); and deficient helper activity in T cells (six of 10), TG+ cells (five of nine), and TG- cells (three of nine). Greater than 50% suppression of Ig synthesis was detected with T cells (four of 10), TG+ cells (three of 10), and TG- cells (three of 10). This study provides evidence for variable regulatory function of Fc receptor T cell subsets in patients with chronic GVHD. The unexpected finding was that TG+ and TG- subpopulations can lack helper activity or actively suppress Ig synthesis.

Citing Articles

Fc receptor--more answers, more questions.

Fornusek L, Vetvicka V Folia Microbiol (Praha). 1984; 29(6):476-516.

PMID: 6396178 DOI: 10.1007/BF02873160.

Bone marrow transplantation in man. Analysis of T and B cell functions in PWM driven Ig production.

Rumke H, Terpstra F, Roos M, Vossen J, DOOREN L, Schellekens P Clin Exp Immunol. 1984; 57(2):467-78.

PMID: 6235992 PMC: 1536117.

The transfer of antigen-specific humoral immunity from marrow donors to marrow recipients.

Lum L, Seigneuret M, Storb R J Clin Immunol. 1986; 6(5):389-96.

PMID: 2429980 DOI: 10.1007/BF00915378.

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