Has the Raphe Dorsalis Nucleus an Asymmetric Function?

Overview

Journal Exp Brain Res

Specialty Neurology

Date 1984 Jan 1

PMID 6209158

Authors

F Crespi

M Jouvet

Affiliations

Soon will be listed here.

Abstract

Differential pulse voltammetry (DPV) was used to measure 5-hydroxyindoles in the striata of anaesthetized rats. The amplitude of the voltammetry peaks in both striata decreased when 5-hydroxytryptophan (5-HTP) or 5-hydroxytryptamine (5-HT) was injected into the left side of the raphe dorsalis nucleus (RDN), but increased when either substance was injected into the right side. These findings indicate that the 5-hydroxyindole based communication between the striata and the RDN has a lateral asymmetry. The data are discussed with reference to histological observations suggesting a higher density of 5-hydroxyindole containing cell bodies in the lateral region than in the midline of this "unpaired" nucleus.

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