Inhibition of the Recovery from Potentially Lethal Damage by Lonidamine

Overview

Journal Br J Cancer

Specialty Oncology

Date 1984 Nov 1

PMID 6208924

Citations 15

Authors

G M Hahn

I van Kersen

B Silvestrini

Affiliations

Soon will be listed here.

Abstract

Lonidamine [1-(2,4-dichlorobenzyl)-1-H-indazol-3-carboxylic acid] is shown to inhibit recovery from potentially lethal damage after exposure of cells to X-rays, methyl methane sulfonate, or bleomycin and heat (43 degrees C, 1h). Inhibition is most effective when the drug is present before and after exposure of 10 to 25 mg l-1, a concentration readily achievable in vivo.

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The Potential of Lonidamine in Combination with Chemotherapy and Physical Therapy in Cancer Treatment.

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Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification.

Lyons J, Song C, Ross B J Neurooncol. 1998; 36(2):149-57.

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Stimulation of the apoptotic response as a basis for the therapeutic synergism of lonidamine and cisplatin in combination in human tumour xenografts.

De Cesare M, Pratesi G, Giusti A, Polizzi D, Zunino F Br J Cancer. 1998; 77(3):434-9.

PMID: 9472640 PMC: 2151278. DOI: 10.1038/bjc.1998.69.

References

Phillips R, Tolmach L . Repair of potentially lethal damage in x-irradiated HeLa cells. Radiat Res. 1966; 29(3):413-32. View

Hahn G, Little J . Plateau-phase cultures of mammalian cells: an in vitro model for human cancer. Curr Top Radiat Res Q. 1972; 8(1):39-43. View

Evans R, Bagshaw M, Gordon L, Kurkjian S, Hahn G . Modification of recovery from potentially lethal x-ray damage in plateau phase Chinese hamster cells. Radiat Res. 1974; 59(3):597-605. View

Braun J, Hahn G . Enhanced cell killing by bleomycin and 43 degrees hyperthermia and the inhibition of recovery from potentially lethal damage. Cancer Res. 1975; 35(11 Pt 1):2921-7. View

Twentyman P, Bleehen N . Studies of "potentially lethal damage" in EMT6 mouse tumour cells treated with bleomycin either in vitro or in vivo. Br J Cancer. 1975; 32(4):491-501. PMC: 2024758. DOI: 10.1038/bjc.1975.251. View

Weichselbaum R, Little J, Nove J . Response of human osteosarcoma in vitro to irradiation: evidence for unusual cellular repair activity. Int J Radiat Biol Relat Stud Phys Chem Med. 1977; 31(3):295-9. DOI: 10.1080/09553007714550351. View

Hahn G . Recovery of cells from induced, potentially lethal damage. Cancer Treat Rep. 1976; 60(12):1791-8. View

Utsumi H, Elkind M . Potentially lethal damage versus sublethal damage: independent repair processes in actively growing Chinese hamster cells. Radiat Res. 1979; 77(2):346-60. View

Guichard M, Malaise E . Influence of misonidazole on the radiosensitivity of a human melanoma in nude mice: time-dependent increase in surviving fraction. Int J Radiat Oncol Biol Phys. 1979; 5(4):487-9. DOI: 10.1016/0360-3016(79)90811-3. View

10.

Iliakis G . Effects of beta-arabinofuranosyladenine on the growth and repair of potentially lethal damage in Ehrilch ascites tumor cells. Radiat Res. 1980; 83(3):537-52. View

11.

Wolters H, Konings A . Radiation effects on membranes. III. The effect of X irradiation on survival of mammalian cells substituted by polyunsaturated fatty acids. Radiat Res. 1982; 92(3):474-82. View