Collagenase and Elastase in the Serum of Adjuvant Arthritic Rats

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1984 Jun 1

PMID 6206699

Authors

D P Parrott

D A Lewis

Affiliations

Soon will be listed here.

Abstract

Collagenase and elastase activities in the serum of adjuvant arthritic rats declined with time as the disease progressed and did not parallel increases in alpha 1-macroglobulin or alpha 2-acute phase globulin levels. The fall in collagenase and elastase activities was accompanied by a decline in serum alpha 1-proteinase inhibitor levels. It was concluded that the fall in collagenase and elastase activities in serum was due to inactivation by serum anti-proteases.

References

Janoff A . Human granulocyte elastase. Further delineation of its role in connective tissue damage. Am J Pathol. 1972; 68(3):579-92. PMC: 2032757. View

. Measurement of alpha 1-antitrypsin in serum, by immunodiffusion and by enzymatic assay. Clin Chem. 1974; 20(3):396-9. View

Miesch F, Bieth J, Metais P . The alpha 1-antitrypsin and alpha 2-macroglobulin content and the protease-inhibiting capacity of normal and pathological sera. Clin Chim Acta. 1971; 31(1):231-41. DOI: 10.1016/0009-8981(71)90382-2. View

Lewis D, Parrott D . The effect of cortisol on alpha1-macro-globulin and alpha2-acute phase globulin in the arthritic rat [proceedings]. Br J Pharmacol. 1976; 58(3):441P-442P. PMC: 1667559. View

Schnebli H . Adjuvant-induced inflammatory disease in the rat: plasma levels of peptide hydrolases and protease inhibitors reflect disease activity. Agents Actions. 1979; 9(5-6):497-501. DOI: 10.1007/BF01968118. View

NEWBOULD B . CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT. Br J Pharmacol Chemother. 1963; 21:127-36. PMC: 1703866. DOI: 10.1111/j.1476-5381.1963.tb01508.x. View

Ohlsson K . Elimination of 125-I-trypsin alpha-macroglobulin complexes from blood by reticuloendothelial cells in dogs. Acta Physiol Scand. 1971; 81(2):269-72. DOI: 10.1111/j.1748-1716.1971.tb04900.x. View

Burstein M, Scholnick H . Lipoprotein-polyanion-metal interactions. Adv Lipid Res. 1973; 11:67-108. View

LAURELL C . Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal Biochem. 1966; 15(1):45-52. DOI: 10.1016/0003-2697(66)90246-6. View

10.

Ganrot K . Rat alpha2-acute phase globulin, a human alpha2-macroglobulin homologue. Interaction with plasmin and trypsin. Biochim Biophys Acta. 1973; 322(1):62-7. DOI: 10.1016/0005-2795(73)90175-x. View

11.

Sachar L, WINTER K, SICHER N, Frankel S . Photometric method for estimation of elastase activity. Proc Soc Exp Biol Med. 1955; 90(2):323-6. DOI: 10.3181/00379727-90-22022. View

12.

Meyer J, Bieth J, Metais P . On the inhibition of elastase by serum. Some distinguishing properties of alpha1-antitrypsin and alpha2-macroglobulin. Clin Chim Acta. 1975; 62(1):43-53. DOI: 10.1016/0009-8981(75)90278-8. View

13.

Ganrot P . Determination of alpha-2-macroglobulin as trypsin-protein esterase. Clin Chim Acta. 1966; 14(4):493-501. DOI: 10.1016/0009-8981(66)90037-4. View

14.

Harris J, Spencer P . A modified plethysmographic apparatus for recording volume changes in the rat paw. J Pharm Pharmacol. 1962; 14:464-6. DOI: 10.1111/j.2042-7158.1962.tb11125.x. View

15.

Parrott D, Lewis D . Protease and antiprotease levels in blood of arthritic rats. Ann Rheum Dis. 1977; 36(2):166-9. PMC: 1006653. DOI: 10.1136/ard.36.2.166. View

16.

BAUMSTARK J . Studies on the elastase-serum protein interaction. II. On the digestion of human a2-macroglobulin, an elastase inhibitor, by elastase. Biochim Biophys Acta. 1970; 207(2):318-30. DOI: 10.1016/0005-2795(70)90024-3. View

17.

Okubo H, Miyanaga O, Nagano M, Ishibashi H, Kudo J, Ikuta T . Purification and immunological determination of alpha 2-macroglobulin in serum from injured rats. Biochim Biophys Acta. 1981; 668(2):257-67. DOI: 10.1016/0005-2795(81)90033-7. View

18.

Coffey J, SALVADOR R . Levels of collagenolytic activity, beta-glucuronidase, and collagen prolyl hydroxylase in paws from rats with developing adjuvant arthritis. Biochim Biophys Acta. 1981; 677(2):243-52. DOI: 10.1016/0304-4165(81)90091-x. View

19.

STEVEN F, Hunter J . A neutral protease in rheumatoid synovial fluid capable of attacking the telopeptide regions of polymeric collagen fibrils. Biochim Biophys Acta. 1975; 405(1):188-200. DOI: 10.1016/0005-2795(75)90329-3. View