Class 1 Major Histocompatibility Complex Antigens on Human Extra-villous Trophoblast

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1984 Jul 1

PMID 6204930

Citations 46

Authors

C W Redman

A J McMichael

G M Stirrat

C A Sunderland

A Ting

Affiliations

Soon will be listed here.

Abstract

Using immunohistological techniques, class 1 products of the major histocompatibility complex (MHC) have been demonstrated on various forms of human extra-villous trophoblast in placental tissues taken from first, second and third trimester pregnancies. This contrasts with the absence of class 1 MHC antigens on all forms of villous trophoblast. The extra-villous trophoblast which reacted with antibodies to monomorphic class 1 MHC antigens consistently failed to bind HLA-A or HLA-B antibodies specific for the foetal phenotype. This suggests, but does not prove, that the MHC antigen expression of trophoblast may be restricted to HLA-C or some other undefined class 1 antigen.

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