Pluripotential Nature of Mesotheliomata Induced by Inhalation of Erionite in Rats

Overview

Journal Br J Exp Pathol

Specialty Pathology

Date 1984 Jun 1

PMID 6204669

Citations 5

Authors

N F Johnson

R E Edwards

D E MUNDAY

N Rowe

J C Wagner

Affiliations

Soon will be listed here.

Abstract

Mesotheliomata can be induced more rapidly and more frequently by inhalation of erionite than by asbestos inhalation. Erionite-induced tumours have in general a similar ultrastructural appearance to inoculum-induced pleural and peritoneal mesotheliomata. Unusual features of these tumours were the presence of dense-cored vesicles and cells staining positively for neuron-specific enolase which indicated the presence of endocrine cells. In addition, one tumour showed differentiation towards bone-forming cells. The expression of both epithelial and mesodermal characteristics demonstrates the pluripotential nature of mesothelial cells under certain circumstances.

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