Mechanism of Histamine Release from Rat Isolated Peritoneal Mast Cells by Dextran: the Role of Immunoglobulin E

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1984 Apr 1

PMID 6203369

Citations 8

Authors

T H Hanahoe

Affiliations

Soon will be listed here.

Abstract

In vivo passive sensitization of rat peritoneal mast cells with Nippostrongylus braziliensis antiserum or rat monoclonal myeloma IgE greatly enhanced histamine release in vitro by dextran or anti IgE, but did not alter release by compound 48/80 or A23187. Conversely, removal of IgE from the cells by acid pH abolished histamine release by dextran and anti IgE but did not impair release by compound 48/80. Whereas, histamine release from cells isolated from rats genetically resistant to dextran (NR rats) by anti IgE was potentiated by passive sensitization, dextran was unable to stimulate secretion from control or sensitized NR cells. The results suggest that dextran releases histamine by interaction with cell-fixed IgE and that the NR mast cell membrane lacks the ability to interpret this stimulus.

Citing Articles

Imaging FITC-dextran as a Reporter for Regulated Exocytosis.

Klein O, Roded A, Hirschberg K, Fukuda M, Galli S, Sagi-Eisenberg R J Vis Exp. 2018; (136).

PMID: 29985342 PMC: 6101964. DOI: 10.3791/57936.

Suppressive effect of 2-phenyl-4-quinolone (YT-1) on hind-paw edema and cutaneous vascular plasma extravasation in mice.

Wang J, Hsu M, Raung S, Kuo S Naunyn Schmiedebergs Arch Pharmacol. 1994; 349(3):324-30.

PMID: 8208310 DOI: 10.1007/BF00169300.

The inhibitory effect of magnolol on cutaneous permeability in mice is probably mediated by a nonselective vascular hyporeactivity to mediators.

Wang J, Raung S, Chen C, Kuo J, Teng C Naunyn Schmiedebergs Arch Pharmacol. 1993; 348(6):663-9.

PMID: 8133909 DOI: 10.1007/BF00167245.

Proceedings of the British Pharmacological Society. University of Dundee, 11th-14th September, 1984. Abstracts.

Br J Pharmacol. 1984; 83 Suppl:349P-463P.

PMID: 6509265 PMC: 1986970.

On the mechanism of dextran-induced histamine secretion from rat peritoneal mast cells.

Thompson H, Leoutsakos A, Pearce F Agents Actions. 1987; 20(3-4):169-71.

PMID: 2440262 DOI: 10.1007/BF02074659.

References

Goth A . Inhibition of anaphylactoid edema in the rat by 2-deoxyglucose. Am J Physiol. 1959; 197:1056-8. DOI: 10.1152/ajplegacy.1959.197.5.1056. View

Ludowyke R, WEST G, Harris J, Hanahoe T . A possible link between the ability of rat isolated peritoneal mast cells to release histamine when challenged with dextran and the proteins in their plasma membranes. Int Arch Allergy Appl Immunol. 1982; 68(2):188-91. DOI: 10.1159/000233094. View

Siraganian R, Siragania P . Mechanism of action of concanavalin A on human basophils. J Immunol. 1975; 114(2 pt 2):886-93. View

Hanahoe T, Tanner T, WEST G . Resistance of rats to the potentiating action of phosphatidyl serine on dextran responses. J Pharm Pharmacol. 1973; 25(5):429-31. DOI: 10.1111/j.2042-7158.1973.tb10046.x. View

Hirata F, Axelrod J . Phospholipid methylation and biological signal transmission. Science. 1980; 209(4461):1082-90. DOI: 10.1126/science.6157192. View

Pearce F . Calcium and histamine secretion from mast cells. Prog Med Chem. 1982; 19:59-109. DOI: 10.1016/s0079-6468(08)70328-x. View

da Silva W, Fernandes A . STUDY OF THE MECHANISM OF INHIBITION PRODUCED BY HEXOSES ON HISTAMINE RELEASE ACTIVITY OF DEXTRAN. Experientia. 1965; 21:96-7. DOI: 10.1007/BF02144764. View

Morita Y, Siraganian R . Inhibition of IgE-mediated histamine release from rat basophilic leukemia cells and rat mast cells by inhibitors of transmethylation. J Immunol. 1981; 127(4):1339-44. View

READ G, Kiefer E . Benzalkonium chloride: selective inhibitor of histamine release induced by compound 48/80 and other polyamines. J Pharmacol Exp Ther. 1979; 211(3):711-5. View

10.

Ishizaka T, Ishizaka K . Mechanisms of passive sensitization. IV. Dissociation of IgE molecules from basophil receptors at acid pH. J Immunol. 1974; 112(3):1078-84. View

11.

Hanahoe T, Holliman A, Gordan D, Wieczorek W . Disodium cromoglycate and the dextran response in rats. J Pharm Pharmacol. 1972; 24(8):666-7. DOI: 10.1111/j.2042-7158.1972.tb09085.x. View

12.

ISERSKY C, Kulczycki Jr A, Metzger H . Isolation of IgE from reaginic rat serum. J Immunol. 1974; 112(5):1909-19. View

13.

ANTON A, SAYRE D . A modified fluorometric procedure for tissue histamine and its distribution in various animals. J Pharmacol Exp Ther. 1969; 166(2):285-90. View

14.

Moodley I, MONGAR J, Foreman J . Histamine release induced by dextran: the nature of the dextran receptor. Eur J Pharmacol. 1982; 83(1-2):69-81. DOI: 10.1016/0014-2999(82)90287-4. View

15.

READ G, Hong S, Kiefer E . Competitive inhibition of 48/80-induced histamine release by benzalkonium chloride and its analogs and the polyamine receptor in mast cells. J Pharmacol Exp Ther. 1982; 222(3):652-7. View

16.

Goth A, Adams H, KNOOHUIZEN M . Phosphatidylserine: selective enhancer of histamine release. Science. 1971; 173(4001):1034-5. DOI: 10.1126/science.173.4001.1034. View

17.

Hirata F, Axelrod J, Crews F . Concanavalin A stimulates phospholipid methylation and phosphatidylserine decarboxylation in rat mast cells. Proc Natl Acad Sci U S A. 1979; 76(10):4813-6. PMC: 413027. DOI: 10.1073/pnas.76.10.4813. View

18.

Goth A, NASH W, Nagler M, Holman J . Inhibition of histamine release in experimental diabetes. Am J Physiol. 1957; 191(1):25-8. DOI: 10.1152/ajplegacy.1957.191.1.25. View

19.

Kulczycki Jr A, Metzger H . The interaction of IgE with rat basophilic leukemia cells. II. Quantitative aspects of the binding reaction. J Exp Med. 1974; 140(6):1676-95. PMC: 2139755. DOI: 10.1084/jem.140.6.1676. View

20.

Shore P, BURKHALTER A, COHN Jr V . A method for the fluorometric assay of histamine in tissues. J Pharmacol Exp Ther. 1959; 127:182-6. View