A Striatal Serotonergic Involvement in the Behavioural Effects of Anticholinesterase Organophosphates

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 1984 Feb 10

PMID 6201369

Citations 4

Authors

J C Fernando

B H Hoskins

I K Ho

Affiliations

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Abstract

Acute administration of the anticholinesterase agents diisopropylfluorophosphate, soman, sarin and tabun to rats in sub-convulsive doses produced tremors and hind-limb abduction. The ratios of the levels of 5-HIAA to 5-HT in the striatum showed a consistent tendency to be increased, suggesting an increase in 5-HT turnover. Both the behavioural and the biochemical changes were antagonized by atropine. The possible involvement of a cholinergic-serotonergic interaction in these tremors and hind-limb abduction is discussed.

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