Phenotypic Characterization of Cells Within Subcutaneous Rheumatoid Nodules

Overview

Journal Arthritis Rheum

Specialty Rheumatology

Date 1983 Nov 1

PMID 6196033

Citations 7

Authors

E Hedfors

L Klareskog

S Lindblad

U Forsum

G Lindahl

Affiliations

Soon will be listed here.

Abstract

An immunohistochemical double-staining technique was applied to frozen sections of biopsies from subcutaneous rheumatoid nodules. Material within the central necrosis reacted with anti-immunoglobulin and anti-HLA-DR antibodies. Cells within the palisading layer were "macrophage-like," as indicated by staining for anti-HLA-DR and OKM1, and showed a high proliferative activity as seen by OKT9 reactivity. The granulation zone contained many (alpha Leu-1+) T cells in close contact with HLA-DR-expressing non-T cells.

Citing Articles

Microchimerism in the rheumatoid nodules of patients with rheumatoid arthritis.

Chan W, Atkins C, Naysmith D, van der Westhuizen N, Woo J, Nelson J Arthritis Rheum. 2011; 64(2):380-8.

PMID: 21953057 PMC: 3258459. DOI: 10.1002/art.33358.

Palisading cells of rheumatoid nodules: comparison with synovial intimal cells.

Edwards J, Wilkinson L, Pitsillides A Ann Rheum Dis. 1993; 52(11):801-5.

PMID: 7504437 PMC: 1005192. DOI: 10.1136/ard.52.11.801.

Epithelial HLA-DR expression and T lymphocyte subsets in salivary glands in Sjögren's syndrome.

Lindahl G, Hedfors E, Klareskog L, Forsum U Clin Exp Immunol. 1985; 61(3):475-82.

PMID: 3907899 PMC: 1577280.

Comparison of phenotype expression by mononuclear phagocytes within subcutaneous gouty tophi and rheumatoid nodules.

Palmer D, Hogg N, Denholm I, Allen C, Highton J, Hessian P Rheumatol Int. 1987; 7(5):187-93.

PMID: 3321380 DOI: 10.1007/BF00541376.

Immunohistology of rheumatoid nodules and rheumatoid synovium.

Athanasou N, Quinn J, Woods C, Mcgee J Ann Rheum Dis. 1988; 47(5):398-403.

PMID: 2968782 PMC: 1003533. DOI: 10.1136/ard.47.5.398.