Ocular Responses Evoked by Capsaicin and Prostaglandin E2 Are Inhibited by a Substance P Antagonist

Overview

Journal Experientia

Specialty Science

Date 1983 Sep 15

PMID 6193006

Citations 4

Authors

G Bynke

R Hakanson

J Horig

Affiliations

Soon will be listed here.

Abstract

Injection of capsaicin or prostaglandin E2 into the vitreous chamber of the rabbit eye resulted in miosis and breakdown of the blood-aqueous barrier, manifested in aqueous flare. Pretreatment with the neuronal blocker tetrodotoxin or the substance P antagonist (D-Pro, D-Trp)-SP greatly reduced the ocular responses to capsaicin and prostaglandin E2. The results suggest a role for neuronal substance P in the ocular response to injury.

Citing Articles

Long-term administration of a substance P antagonist, (D-Pro2, D-Trp7,9)-SP, abolishes the response to ocular trauma.

Bynke G, Hakanson R, Horig J, Folkers K Experientia. 1984; 40(4):368-9.

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Neurogenic inflammation in skin blisters.

Helme R, White D, Andrews P Exp Brain Res. 1985; 59(2):382-7.

PMID: 4029311 DOI: 10.1007/BF00230918.

Sympathectomy enhances the substance P-mediated breakdown of the blood-aqueous barrier in response to infrared irradiation of the rabbit iris.

Bynke G, Bruun A, Hakanson R Experientia. 1985; 41(4):488-9.

PMID: 2580736 DOI: 10.1007/BF01966163.

Substance P antagonists and mucociliary activity in rabbit.

Lindberg S, Mercke U Naunyn Schmiedebergs Arch Pharmacol. 1985; 329(4):376-81.

PMID: 2412138 DOI: 10.1007/BF00496371.

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