Histamine Secretion in Leukocyte Incubates of Patients with Allergic Hyperreactivity Induced by Somatostatin-14 and Somatostatin-28

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1983 Apr 1

PMID 6191551

Citations 1

Authors

F Diel

N Bethge

W Opree

Affiliations

Soon will be listed here.

Abstract

Somatostatin is a potent histamine secretagogue found not only in rat mast cells but also in human leukocyte preparations. In concentrations greater than or equal to 5 mumol/l, somatostatin-14 induces histamine release, which correlates with the basophilic blood cell count, as shown in samples from allergic patients suffering from slight basophilia. Somatostatin-14 is twice as effective as somatostatin-28 on a molar basis, and acylating the tetradecapeptide with N-hydroxysuccinimidyl-p-hydroxy-phenyl-propionate decreases significantly the potency of histamine release.

Citing Articles

Somatostatin-induced histamine release in mast cell incubates from thymusaplastic nude rats.

Diel F, Usadel K Agents Actions. 1984; 14(3-4):506-9.

PMID: 6203374 DOI: 10.1007/BF01973860.

References

Diel F, Schneider E, Quabbe H . Development of a radioimmunoassay for cyclic somatostatin: antibody production, comparative radioiodination, and dose-response curve. J Clin Chem Clin Biochem. 1977; 15(12):669-77. DOI: 10.1515/cclm.1977.15.1-12.669. View

Theoharides T, BETCHAKU T, DOUGLAS W . Somatostatin-induced histamine secretion in mast cells. Characterization of the effect. Eur J Pharmacol. 1981; 69(2):127-37. DOI: 10.1016/0014-2999(81)90407-6. View

Pradayrol L, Jornvall H, Mutt V, Ribet A . N-terminally extended somatostatin: the primary structure of somatostatin-28. FEBS Lett. 1980; 109(1):55-8. DOI: 10.1016/0014-5793(80)81310-x. View

Vale W, BRAZEAU P, Rivier C, Brown M, Boss B, Rivier J . Somatostatin. Recent Prog Horm Res. 1975; 31:365-97. DOI: 10.1016/b978-0-12-571131-9.50014-1. View

Kazimierczak W, DIAMANT B . Mechanisms of histamine release in anaphylactic and anaphylactoid reactions. Prog Allergy. 1978; 24:295-365. View