IgG2 Deficiency in a Healthy Blood Donor. Concomitant Lack of IgG2, IgA and IgE Immunoglobulins and Specific Anti-carbohydrate Antibodies

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1983 Mar 1

PMID 6189654

Citations 21

Authors

L Hammarstrom

C I Smith

Affiliations

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Abstract

Lack of serum IgG2, IgA and IgE was found in a healthy male adult blood donor. No secretory IgA could be demonstrated. In vitro activation of lymphocytes did not induce IgA secreting cells although no class specific suppressor cells could be found. Normal or slightly subnormal titres to a variety of bacterial and viral antigens were demonstrated whereas anti-carbohydrate antibodies (anti-teichoic acid, anti-dextran and anti-pneumococcal polysaccharide) were virtually absent. Isoagglutinins and heteroagglutinins were present in somewhat lower concentrations than normal.

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