Tunicamycin Enhances the Antiviral and Anticellular Activity of Interferon
Affiliations
The inhibitory effects of interferon on virus multiplication and cell growth are significantly enhanced by treatment with tunicamycin. Potentiation of antiviral activity was found only with enveloped viruses and not with nonbudding viruses. Changes in the plasma membrane of treated cells may account for this effect, since enveloped viruses bud from the cell surface as a terminal step.
Interferon-α alters host glycosylation machinery during treated HIV infection.
Giron L, Colomb F, Papasavvas E, Azzoni L, Yin X, Fair M EBioMedicine. 2020; 59:102945.
PMID: 32827942 PMC: 7452630. DOI: 10.1016/j.ebiom.2020.102945.
Tunicamycin treatment inhibits the antiviral activity of interferon in mice.
Maheshwari R, Husain M, Attallah A, Friedman R Infect Immun. 1983; 41(1):61-6.
PMID: 6190759 PMC: 264743. DOI: 10.1128/iai.41.1.61-66.1983.