Suppressor Mechanisms in Tumor Immunity

Overview

Journal Experientia

Specialty Science

Date 1983 Mar 15

PMID 6186519

Citations 9

Authors

G T Nepom

I Hellstrom

K E Hellstrom

Affiliations

Soon will be listed here.

Abstract

There are many parallels between T cell-mediated suppression of tumor immunity and suppression of immune responses to haptens and polypeptides. We propose a cell interaction model which takes this into account and outlines a regulatory pathway for suppression of immunity to tumor antigens. Free antigen or antigen/antibody complexes trigger an inducer T cell subset, Tsi, which is tumor-specific. This cell activates a non-immune T cell population, pre Tse, to generate effector suppressor cells, Tse. The Tse are specific for either the idiotype of Tsi or for antigen complexed with a soluble factor made by the Tsi, but the suppression they mediate is antigenically nonspecific. Tumor antigen-specific suppressor factors, TsF, play a major role in the communication between different suppressor cells. Characterization of polyclonal and monoclonal factors produced by Tsi, called TsFi, indicates that they both bind to tumor antigen and contain tumor-specific (idiotypic?) determinants.

Citing Articles

Induction of immunity to a human tumor marker by in vivo administration of anti-idiotypic antibodies in mice.

Nepom G, Nelson K, Holbeck S, Hellstrom I, Hellstrom K Proc Natl Acad Sci U S A. 1984; 81(9):2864-7.

PMID: 6609369 PMC: 345172. DOI: 10.1073/pnas.81.9.2864.

Immune reactivity in SL2 lymphoma-bearing mice compared with SL2-immunized mice.

de Weger R, Wilbrink B, Moberts R, Mans D, Oskam R, Den Otter W Cancer Immunol Immunother. 1987; 24(1):25-36.

PMID: 3493070 PMC: 11038171. DOI: 10.1007/BF00199829.

Recombinant vaccinia virus vaccine against the human melanoma antigen p97 for use in immunotherapy.

Estin C, Stevenson U, Plowman G, Hu S, Sridhar P, Hellstrom I Proc Natl Acad Sci U S A. 1988; 85(4):1052-6.

PMID: 3422478 PMC: 279699. DOI: 10.1073/pnas.85.4.1052.

Immune surveillance and natural resistance: an evaluation.

Den Otter W Cancer Immunol Immunother. 1986; 21(2):85-92.

PMID: 2936448 PMC: 11037998. DOI: 10.1007/BF00199854.

Anti-idiotypic antibodies and the induction of specific tumor immunity.

Nepom G, Hellstrom K Cancer Metastasis Rev. 1987; 6(4):489-502.

PMID: 2450687 DOI: 10.1007/BF00047464.

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