Combined Interaction of Antiherpes Substances and Interferon Beta on the Multiplication of Herpes Simplex Virus

Overview

Journal Arch Virol

Specialty Microbiology

Date 1982 Jan 1

PMID 6184033

Citations 8

Authors

C Janz

R Wigand

Affiliations

Soon will be listed here.

Abstract

The inhibition of herpes simplex virus type 1 (strain McIntyre) by two anti-herpes substances applied in combination was studied by means of a CPE inhibition method In Vero cell microcultures. The following substances were studied: AraA monophosphate, thymine arabinoside, ethyldeoxyuridine, acycloguanosine (acyclovir). 3-fluorothymidine, phosphonoformic acid. Most substance pairs showed a moderate degree of synergism. Two additive interactions and one case of antagonism was observed. Human fibroblast interferon, combined with the antiherpes substances, showed an additive interaction with AraAMP, but synergism with the others.

Citing Articles

Enhanced efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine in combination with beta-interferon against herpes simplex virus type 2 in mice.

Eppstein D, Marsh Y, Matthews T Antimicrob Agents Chemother. 1984; 25(5):563-5.

PMID: 6610387 PMC: 185586. DOI: 10.1128/AAC.25.5.563.

Enhanced efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine in combination with alpha-interferon against herpes simplex virus type 2 in mice.

Eppstein D, Marsh Y, Matthews T Antimicrob Agents Chemother. 1984; 26(6):937-8.

PMID: 6335382 PMC: 180056. DOI: 10.1128/AAC.26.6.937.

Antiviral effects of bovine interferons on bovine respiratory tract viruses.

Fulton R, Downing M, Cummins J J Clin Microbiol. 1984; 19(4):492-7.

PMID: 6201505 PMC: 271102. DOI: 10.1128/jcm.19.4.492-497.1984.

Cutaneous herpes simplex virus infection of the guinea pig: lack of resistance to acyclovir and phosphonoformic acid after topical treatment.

Poryo A, Wigand R Med Microbiol Immunol. 1984; 173(4):219-24.

PMID: 6096685 DOI: 10.1007/BF02122113.

Synergistic effect of human leukocyte interferon and nonoxynol 9 against herpes simplex virus type 2.

Rapp F, Wrzos H Antimicrob Agents Chemother. 1985; 28(3):449-51.

PMID: 3000288 PMC: 180273. DOI: 10.1128/AAC.28.3.449.

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