Use of Monoclonal Antibodies for the Histopathological Diagnosis of Human Malignancy

Overview

Journal J Clin Pathol

Specialty Pathology

Date 1982 Nov 1

PMID 6183295

Citations 51

Authors

K C Gatter

Z Abdulaziz

P Beverley

J R Corvalan

C Ford

E B Lane

M Mota

J R Nash

K Pulford

H STEIN

J Taylor-Papadimitriou

C Woodhouse

D Y Mason

Affiliations

Soon will be listed here.

Abstract

This paper describes the use of a panel of seven monoclonal antibodies (selected so as to include reagents reactive with both epithelial and lymphoid cells) for distinguishing between anaplastic carcinoma and high grade lymphoma. Details are given of the immunohistological reactions of these antibodies against a wide range of both normal and malignant tissues and of a number of practical instances in which use of the antibody panel enabled a diagnosis to be made when routine histological examination had been inconclusive.

Citing Articles

Lymphoma versus Carcinoma and Other Collaborations.

Pulford K Cells. 2022; 11(1).

PMID: 35011737 PMC: 8750236. DOI: 10.3390/cells11010174.

Proteomes Are of Proteoforms: Embracing the Complexity.

Carbonara K, Andonovski M, Coorssen J Proteomes. 2021; 9(3).

PMID: 34564541 PMC: 8482110. DOI: 10.3390/proteomes9030038.

In situ tissue engineering with synthetic self-assembling peptide nanofiber scaffolds, PuraMatrix, for mucosal regeneration in the rat middle-ear.

Akiyama N, Yamamoto-Fukuda T, Takahashi H, Koji T Int J Nanomedicine. 2013; 8:2629-40.

PMID: 23926427 PMC: 3728305. DOI: 10.2147/IJN.S47279.

Newer developments in immunohistology.

Leong A, Leong T J Clin Pathol. 2006; 59(11):1117-26.

PMID: 17071800 PMC: 1860504. DOI: 10.1136/jcp.2005.031179.

Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease.

Selby W, Janossy G, Mason D, Jewell D Clin Exp Immunol. 1983; 53(3):614-8.

PMID: 6577996 PMC: 1535633.

References

MATOLTSY A . Desmosomes, filaments, and keratohyaline granules: their role in the stabilization and keratinization of the epidermis. J Invest Dermatol. 1975; 65(1):127-42. DOI: 10.1111/1523-1747.ep12598093. View

Goldenberg D, Sharkey R, Primus F . Carcinoembryonic antigen in histopathology: immunoperoxidase staining of conventional tissue sections. J Natl Cancer Inst. 1976; 57(1):11-22. DOI: 10.1093/jnci/57.1.11. View

Heyderman E, Neville A . A shorter immunoperoxidase technique for the demonstration of carcinoembryonic antigen and other cell products. J Clin Pathol. 1977; 30(2):138-40. PMC: 476336. DOI: 10.1136/jcp.30.2.138. View

Sun T, Green H . Keratin filaments of cultured human epidermal cells. Formation of intermolecular disulfide bonds during terminal differentiation. J Biol Chem. 1978; 253(6):2053-60. View

Franke W, Weber K, Osborn M, Schmid E, Freudenstein C . Antibody to prekeratin. Decoration of tonofilament like arrays in various cells of epithelial character. Exp Cell Res. 1978; 116(2):429-45. DOI: 10.1016/0014-4827(78)90466-4. View

Forsum U, Klareskog L, Peterson P . Distribution of Ia-antigen-like molecules on non-lymphoid tissues. Scand J Immunol. 1979; 9(4):343-9. DOI: 10.1111/j.1365-3083.1979.tb03172.x. View

Sun T, Shih C, Green H . Keratin cytoskeletons in epithelial cells of internal organs. Proc Natl Acad Sci U S A. 1979; 76(6):2813-7. PMC: 383699. DOI: 10.1073/pnas.76.6.2813. View

Franke W, Appelhans B, Schmid E, Freudenstein C, Osborn M, Weber K . Identification and characterization of epithelial cells in mammalian tissues by immunofluorescence microscopy using antibodies to prekeratin. Differentiation. 1979; 15(1):7-25. DOI: 10.1111/j.1432-0436.1979.tb01030.x. View

Halper J, Knowles 2nd D, Wang C . Ia antigen expression by human malignant lymphomas: correlation with conventional lymphoid markers. Blood. 1980; 55(3):373-82. View

10.

Warnke R, Miller R, Grogan T, Pederson M, Dilley J, Levy R . Immunologic phenotype in 30 patients with diffuse large-cell lymphoma. N Engl J Med. 1980; 303(6):293-300. DOI: 10.1056/NEJM198008073030601. View

11.

Walker R . Demonstration of carcinoembryonic antigen in human breast carcinomas by the immunoperoxidase technique. J Clin Pathol. 1980; 33(4):356-60. PMC: 1146078. DOI: 10.1136/jcp.33.4.356. View

12.

Kadin M . Ia-like (HLA-DR) antigens in the diagnosis of lymphoma and undifferentiated tumors. Arch Pathol Lab Med. 1980; 104(10):503-508. View

13.

Janossy G, Thomas J, Pizzolo G, Granger S, McLaughlin J, Habeshaw J . Immuno-histological diagnosis of lymphoproliferative diseases by selected combinations of antisera and monoclonal antibodies. Br J Cancer. 1980; 42(2):224-42. PMC: 2010398. DOI: 10.1038/bjc.1980.222. View

14.

Loning T, Staquet M, Thivolet J, Seifert G . Keratin polypeptides distribution in normal and diseased human epidermis and oral mucosa. Immunohistochemical study on unaltered epithelium and inflammatory, premalignant and malignant lesions. Virchows Arch A Pathol Anat Histol. 1980; 388(3):273-88. DOI: 10.1007/BF00430859. View

15.

Pizzolo G, Sloane J, Beverley P, Thomas J, Bradstock K, Mattingly S . Differential diagnosis of malignant lymphoma and nonlymphoid tumors using monoclonal anti-leucocyte antibody. Cancer. 1980; 46(12):2640-7. DOI: 10.1002/1097-0142(19801215)46:12<2640::aid-cncr2820461218>3.0.co;2-s. View

16.

Battifora H, Sun T, Bahu R, Rao S . The use of antikeratin antiserum as a diagnostic tool: thymoma versus lymphoma. Hum Pathol. 1980; 11(6):635-41. DOI: 10.1016/s0046-8177(80)80074-8. View

17.

Klareskog L, Forsum U, Peterson P . Hormonal regulation of the expression of Ia antigens on mammary gland epithelium. Eur J Immunol. 1980; 10(12):958-63. DOI: 10.1002/eji.1830101212. View

18.

Franke W, Denk H, Kalt R, Schmid E . Biochemical and immunological identification of cytokeratin proteins present in hepatocytes of mammalian liver tissue. Exp Cell Res. 1981; 131(2):299-318. DOI: 10.1016/0014-4827(81)90234-2. View

19.

Natali P, De Martino C, Quaranta V, Bigotti A, Pellegrino M, Ferrone S . Changes in Ia-like antigen expression on malignant human cells. Immunogenetics. 1981; 12(3-4):409-13. DOI: 10.1007/BF01561680. View

20.

Sloane J, Ormerod M . Distribution of epithelial membrane antigen in normal and neoplastic tissues and it value in diagnostic tumor pathology. Cancer. 1981; 47(7):1786-95. DOI: 10.1002/1097-0142(19810401)47:7<1786::aid-cncr2820470711>3.0.co;2-8. View