» Articles » PMID: 6179851

Five New Gc Variants Detected by Isoelectric Focusing in Agarose Gel

Overview
Journal Hum Genet
Specialty Genetics
Date 1982 Jan 1
PMID 6179851
Citations 8
Authors
Affiliations
Soon will be listed here.
Abstract

Five new genetically determined Gc variants were observed by isoelectric focusing. Seven rare variants 1A4, 1Cl, 1C3, 1C9, 1C11, 2A2, and 2A5 were also found in the material comprising Danish and Swedish paternity cases. All the variants were further analysed by electrophoresis in agarose gel. Two of the new variants had double bands of which the anodal one was susceptible to neuraminidase treatment (Gc 1C13 and 1C14). The three other new variants appeared as a single band, which was unaffected by neuraminidase treatment (Gc 2A9, 2C5, and 2C6). The Gc Ar variant originally detected by electrophoresis was reexamined by isoelectric focusing and named 2C4.

Citing Articles

A new single band variant of the Gc subtypes determined by isoelectric focusing.

Nakasono I, Iwasaki M, Ogata M, Yoshida C, Yoshitake T, Narita K Hum Genet. 1983; 64(2):184-5.

PMID: 6885057 DOI: 10.1007/BF00327122.


The polymorphism of the vitamin D-binding protein (Gc); isoelectric focusing in 3 M urea as additional method for identification of genetic variants.

Constans J, CLEVE H, Dykes D, Fischer M, Kirk R, Papiha S Hum Genet. 1983; 65(2):176-80.

PMID: 6689165 DOI: 10.1007/BF00286658.


A deficiency mutant of the Gc system.

Vavrusa B, CLEVE H, Constans J Hum Genet. 1983; 65(2):102-7.

PMID: 6689164 DOI: 10.1007/BF00286643.


Description of six new Gc variants.

Dykes D, Copouls B, POLESKY H Hum Genet. 1983; 63(1):35-7.

PMID: 6687584 DOI: 10.1007/BF00285394.


Gc subtypes determined by ultrathin-layer isoelectric focusing. Distribution in the Veneto population (Italy).

Cortivo P, Biasiolo M, Caenazzo L, Scorretti C, Benciolini P, Ongaro G Z Rechtsmed. 1984; 93(4):311-5.

PMID: 6543413 DOI: 10.1007/BF00198657.


References
1.
Thymann M . Gc subtypes determined by agarose isoelectrofocusing: distribution in Denmark and application to paternity cases. Hum Hered. 1981; 31(4):214-21. DOI: 10.1159/000153211. View

2.
CLEVE H, Patutschnick W . Neuraminidase treatment reveals sialic acid differences in certain genetic variants of the Gc system (vitamin-D-binding protein). Hum Genet. 1979; 47(2):193-8. DOI: 10.1007/BF00273201. View

3.
Constans J, Viau M . Group-specific component: evidence for two subtypes of the Gc1 gene. Science. 1977; 198(4321):1070-1. DOI: 10.1126/science.73222. View

4.
Constans J, CLEVE H . Group-specific component. Report on the First International Workshop, Collège de France--July 27-28, 1978--Paris. Hum Genet. 1979; 48(2):143-9. DOI: 10.1007/BF00286897. View

5.
Constans J, Viau M, Pison G, Langaney A . Gc subtypes demonstrated by isoelectric focusing: further data and description of new variants among an African sample (Fula) from Senegal. Jinrui Idengaku Zasshi. 1978; 23(2):111-7. DOI: 10.1007/BF02001791. View