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Maintenance of Wakefulness Test: a Polysomnographic Technique for Evaluation Treatment Efficacy in Patients with Excessive Somnolence

Overview
Journal Electroencephalogr Clin Neurophysiol
Publisher Elsevier
Specialties Neurology
Physiology
Date 1982 Jun 1
PMID 6177511
Citations 92
Authors
M M Mitler
K S Gujavarty
C P Browman
Affiliations
Soon will be listed here.
Abstract

Ten patients with narcolepsy were given five 20 min opportunities to remain awake throughout the day. Trials were offered at 2 h intervals beginning at 10:00. Polysomnographic variables were monitored during each trial. Sleep latency increased when patients were instructed to maintain wakefulness compared to when instructed to sleep; however, sleep latencies were still lower for narcoleptics than for control subjects. Unexpectedly, we were not always able to document patients' reports of increased ability to stay awake. The findings suggested that clinical data on symptom control in narcolepsy do not predict ability to stay awake. Objective measures of the ability are potentially more useful in evaluating treatment.

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