The Stimulus-induced Release of 5-hydroxytryptamine and Tryptophan from Superfused Rat Brain Synaptosomes

Overview

Journal J Neural Transm

Specialties Neurology
Physiology

Date 1982 Jan 1

PMID 6176682

Citations 2

Authors

K J Collard

T N EVANS

H A Suter

L S Wilkinson

Affiliations

Soon will be listed here.

Abstract

The synthesis of 5-hydroxytryptamine (5-HT) from 3H-tryptophan in rat forebrain synaptosomes was studied. Synaptosomes which had been preincubated with 3H-tryptophan were perfused with Krebs solution and the release of tryptophan, 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) was determined. K+ depolarization induced a Ca2+ -dependent release of 5-HT and tryptophan but had no effect on 5-HIAA efflux. This finding suggests that the release of tryptophan is unlikely to be a non-specific effect of depolarization.

Citing Articles

The regulation of 5-hydroxytryptamine release from superfused synaptosomes by 5-hydroxytryptamine and its immediate precursors.

Suter H, Collard K Neurochem Res. 1983; 8(6):723-30.

PMID: 6604881 DOI: 10.1007/BF00964729.

Studies on the mechanism by which tryptophan efflux from isolated synaptosomes is stimulated by depolarization.

Collard K, Wilkinson L, Lewis D Br J Pharmacol. 1988; 93(2):341-8.

PMID: 2965950 PMC: 1853795. DOI: 10.1111/j.1476-5381.1988.tb11440.x.

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