Antibody-dependent Plaque Enhancement: Its Antigenic Specificity in Relation to Togaviridae
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The antigenic specificity of antibody-dependent plaque enhancement (ADPE) on the macrophage cell line P388D1 has been investigated using viruses in the flavivirus and alphavirus genera. Whereas ADPE detected group-specific antigenic determinants in the flaviviruses, narrower specificity (type and subgroup) was seen with alphaviruses. ADPE titres correlated well with haemagglutination inhibition titres.
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