Transient Retinofugal Pathways in the Developing Chick

Overview

Journal Exp Brain Res

Specialty Neurology

Date 1982 Jan 1

PMID 6173249

Citations 16

Authors

S C McLoon

R D Lund

Affiliations

Soon will be listed here.

Abstract

The central retinal projections have been examined in normal chick embryos early in development to determine if a transient ipsilateral projection is present. Anterograde transport of HRP identified using tetramethyl benzidine as a chromogen and degeneration techniques were used on embryos of successive ages between 6 and 16 days of incubation to show the central distribution of the retinal axons from one eye. Besides the anticipated contralateral projection, a small projection was identified to primary visual nuclei on the side of the brain ipsilateral to the injected or lesioned eye in embryos between days 6 and 12 of incubation. A projection from the injected eye into the contralateral optic nerve was also identified in a number of embryos. By embryonic day 15 the retinal projection to the ipsilateral side of the brain and into the contralateral optic nerve had disappeared. This loss of the anomalous projections coincides with a period of substantial cell death in the retinal ganglion cell layer. It appears, therefore, that in the chick, like the rat, the ipsilateral retinofugal projection resulting from an embryonic enucleation may in part be due to retention of a normal ipsilateral projection.

Citing Articles

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References

Crossland W, Cowan W, Rogers L . Studies on the development of the chick optic tectum. IV. An autoradiographic study of the development of retino-tectal connections. Brain Res. 1975; 91(1):1-23. DOI: 10.1016/0006-8993(75)90463-1. View

Hamburger V, HAMILTON H . A series of normal stages in the development of the chick embryo. J Morphol. 2014; 88(1):49-92. View

Clarke P, Rogers L, Cowan W . The time of origin and the pattern of survival of neurons in the isthmo-optic nucleus of the chick. J Comp Neurol. 1976; 167(2):125-42. DOI: 10.1002/cne.901670202. View

Rager G, von Oeynhausen B . Ingrowth and ramification of retinal fibers in the developing optic tectum of the chick embryo. Exp Brain Res. 1979; 35(2):213-27. DOI: 10.1007/BF00236612. View

Lund R, LUND J . Synaptic adjustment after deafferentation of the superior colliculus of the rat. Science. 1971; 171(3973):804-7. DOI: 10.1126/science.171.3973.804. View

Rager G, Rager U . Systems-matching by degeneration. I. A quantitative electron microscopic study of the generation and degeneration of retinal ganglion cells in the chicken. Exp Brain Res. 1978; 33(1):65-78. DOI: 10.1007/BF00238795. View

Chihara E . Axoplasmic and nonaxoplasmic transport along the optic pathway of albino rabbits; a theoretical pattern of distribution. Invest Ophthalmol Vis Sci. 1979; 18(4):339-45. View

Clarke P, Cowan W . The development of the isthmo-optic tract in the chick, with special reference to the occurrence and correction of developmental errors in the location and connections of isthmo-optic neurons. J Comp Neurol. 1976; 167(2):143-64. DOI: 10.1002/cne.901670203. View

Haley J, Wisniewski H, Ledeen R . Extra-axonal diffusion in the rabbit optic system: a caution in axonal transport studies. Brain Res. 1979; 179(1):69-76. DOI: 10.1016/0006-8993(79)90490-6. View

10.

Raffin J, Reperant J . [Experimental study of visual projection specificity in microphthalm and monophthalm embryos and adults of Gallus domesticus L]. Arch Anat Microsc Morphol Exp. 1975; 64(2):93-111. View

11.

Dunn B, Boone M . Growth of the chick embryo in vitro. Poult Sci. 1976; 55(3):1067-71. DOI: 10.3382/ps.0551067. View

12.

Goldberg S . Studies on the mechanics of development of the visual pathways in the chick embryo. Dev Biol. 1974; 36(1):24-43. DOI: 10.1016/0012-1606(74)90188-2. View

13.

Bohn R, Stelzner D . Aberrant retino-retinal pathway during early stages of regeneration in adult Rana pipiens. Brain Res. 1979; 160(1):139-44. DOI: 10.1016/0006-8993(79)90608-5. View

14.

Hughes W, McLoon S . Ganglion cell death during normal retinal development in the chick: comparisons with cell death induced by early target field destruction. Exp Neurol. 1979; 66(3):587-601. DOI: 10.1016/0014-4886(79)90204-8. View

15.

Mesulam M . Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. J Histochem Cytochem. 1978; 26(2):106-17. DOI: 10.1177/26.2.24068. View

16.

Land P, Lund R . Development of the rat's uncrossed retinotectal pathway and its relation to plasticity studies. Science. 1979; 205(4407):698-700. DOI: 10.1126/science.462177. View

17.

Lund R, Land P, Boles J . Normal and abnormal uncrossed retinotectal pathways in rats: an HRP study in adults. J Comp Neurol. 1980; 189(4):711-20. DOI: 10.1002/cne.901890407. View

18.

Rager G, Rager U . Generation and degeneration of retinal ganglion cells in the chicken. Exp Brain Res. 1976; 25:551-3. DOI: 10.1007/BF00239787. View

19.

Pettigrew J . Binocular visual processing in the owl's telencephalon. Proc R Soc Lond B Biol Sci. 1979; 204(1157):435-54. DOI: 10.1098/rspb.1979.0038. View

20.

Bunt S, Lund R . Development of a transient retino-retinal pathway in hooded and albino rats. Brain Res. 1981; 211(2):399-404. DOI: 10.1016/0006-8993(81)90712-5. View