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Induction of IgM Memory with RNA from the Spleens of Immunized Mice

Overview
Journal Immunology
Specialty Allergy & Immunology
Date 1981 Nov 1
PMID 6172370
Citations 2
Authors
K Kodama
T Yoshida
T Shibiya
S Kurashige
S Mitsuhashi
Affiliations
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Abstract

Ribonucleic acid (immune RNA, iRNA), extracted from the spleens of mice immunized with sheep red blood cells (SRBC), induced specific immunological memory. The humoral immune responses of iRNA-treated animals were compared with in vivo and in vitro primary and secondary responses, using the haemolytic plaque-forming cell (PFC) assay. IgM antibody formation was markedly higher in iRNA-treated than in any other mice. The effect of iRNA was antigen-specific and similar materials from non-immunized mice had no activity.

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