» Articles » PMID: 6171517

Immunological Nonidentity of Heat-labile Enterotoxins from Human and Porcine Enterotoxigenic Escherichia Coli

Overview
Journal Infect Immun
Date 1981 Nov 1
PMID 6171517
Citations 63
Authors
Affiliations
Soon will be listed here.
Abstract

The Ouchterlony double-gel diffusion test demonstrated that heat-labile enterotoxin (LT) from human strains of enterotoxigenic Escherichia coli was antigenically related but not identical to that from porcine E. coli. All human strains examined produced immunologically identical LTs, and all porcine strains examined produced immunologically identical LTs. The Biken test (modified Elek test), developed for detection of E. coli LT (Honda et al., J. Clin. Microbiol. 13: 1-5, 1981), was useful for confirmation of these results.

Citing Articles

Vibrio parahaemolyticus, enterotoxigenic Escherichia coli, enterohemorrhagic Escherichia coli and Vibrio cholerae.

Takeda Y Proc Jpn Acad Ser B Phys Biol Sci. 2011; 87(1):1-12.

PMID: 21233598 PMC: 3035056. DOI: 10.2183/pjab.87.1.


Functional diversity of heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli: differential enzymatic and immunological activities of LT1 (hLT) AND LT4 (pLT).

Rodrigues J, Mathias-Santos C, Sbrogio-Almeida M, Amorim J, Cabrera-Crespo J, Balan A J Biol Chem. 2010; 286(7):5222-33.

PMID: 21135101 PMC: 3037635. DOI: 10.1074/jbc.M110.173682.


Little heterogeneity among genes encoding heat-labile and heat-stable toxins of enterotoxigenic Escherichia coli strains isolated from diarrheal pigs.

Zhang C, Rausch D, Zhang W Appl Environ Microbiol. 2009; 75(19):6402-5.

PMID: 19684170 PMC: 2753094. DOI: 10.1128/AEM.00952-09.


Genetic diversity of heat-labile toxin expressed by enterotoxigenic Escherichia coli strains isolated from humans.

Lasaro M, Rodrigues J, Mathias-Santos C, Guth B, Balan A, Sbrogio-Almeida M J Bacteriol. 2008; 190(7):2400-10.

PMID: 18223074 PMC: 2293181. DOI: 10.1128/JB.00988-07.


In vitro induction of immunoglobulin A (IgA)- and IgM-secreting plasma blasts by cholera toxin depends on T-cell help and is mediated by CD154 up-regulation and inhibition of gamma interferon synthesis.

Arce S, Nawar H, Muehlinghaus G, Russell M, Connell T Infect Immun. 2007; 75(3):1413-23.

PMID: 17220318 PMC: 1828582. DOI: 10.1128/IAI.01367-06.


References
1.
Finkelstein R, LoSpalluto J . Pathogenesis of experimental cholera. Preparation and isolation of choleragen and choleragenoid. J Exp Med. 1969; 130(1):185-202. PMC: 2138674. DOI: 10.1084/jem.130.1.185. View

2.
Gyles C, Barnum D . A heat-labile enterotoxin from strains of Eschericha coli enteropathogenic for pigs. J Infect Dis. 1969; 120(4):419-26. DOI: 10.1093/infdis/120.4.419. View

3.
Smith N, Sack R . Immunologic cross-reactions of enterotoxins from Escherichia coli and Vibrio cholerae. J Infect Dis. 1973; 127(2):164-70. DOI: 10.1093/infdis/127.2.164. View

4.
Evans D, Evans Jr D, Gorbach S . Identification of enterotoxigenic Escherichia coli and serum antitoxin activity by the vascular permeability factor assay. Infect Immun. 1973; 8(5):731-5. PMC: 422919. DOI: 10.1128/iai.8.5.731-735.1973. View

5.
Donta S . Neutralization of cholera enterotoxin-induced steroidogenesis by specific antibody. J Infect Dis. 1974; 129(3):284-8. DOI: 10.1093/infdis/129.3.284. View