Inhibition by Azelastine of the Immunologically Induced Histamine Release from Isolated Guinea Pig Mast Cells

Overview

Journal Arzneimittelforschung

Specialty Pharmacology

Date 1981 Jan 1

PMID 6170297

Citations 6

Authors

B Fischer

W Schmutzler

Affiliations

Soon will be listed here.

Abstract

4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone (azelastine, A 5610) did not affect the spontaneous histamine release but inhibited effectively the allergic histamine release from isolated mesenteric mast cells of actively sensitized guinea pigs. At 10(-6) mol/l concentration the inhibition was almost equal to that caused by adrenaline (10(-8) mol/l).

Citing Articles

Lipid Cubic Systems for Sustained and Controlled Delivery of Antihistamine Drugs.

Dully M, Ceresnakova M, Murray D, Soulimane T, Hudson S Mol Pharm. 2021; 18(10):3777-3794.

PMID: 34547899 PMC: 8493555. DOI: 10.1021/acs.molpharmaceut.1c00279.

Azelastine and allergen transduction signal in MC9 mast cells.

Fanous K, Garay R Naunyn Schmiedebergs Arch Pharmacol. 1993; 348(5):515-9.

PMID: 7509459 DOI: 10.1007/BF00173212.

Azelastine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential.

McTavish D, Sorkin E Drugs. 1989; 38(5):778-800.

PMID: 2574665 DOI: 10.2165/00003495-198938050-00005.

Histamine2 (H2)-receptor antagonists in the treatment of urticaria.

Theoharides T Drugs. 1989; 37(3):345-55.

PMID: 2565802 DOI: 10.2165/00003495-198937030-00004.

Azelastine inhibits stimulated histamine release from human lung tissue in vitro but does not alter cyclic nucleotide content.

Little M, Wood D, Casale T Agents Actions. 1989; 28(1-2):16-21.

PMID: 2476920 DOI: 10.1007/BF02022975.