Lymphocyte-dependent Antibodies to Antigen 3.1, a Cell-surface Antigen Expressed by a Subgroup of Human Melanomas

Overview

Journal Int J Cancer

Specialty Oncology

Date 1981 Mar 15

PMID 6169659

Citations 9

Authors

I Hellstrom

K E Hellstrom

M Y Yeh

Affiliations

Soon will be listed here.

Abstract

Previous work from our laboratory has led to the isolation of a monoclonal IgG2a mouse antibody, 3.2, which is specific for an antigen, 3.1, that is strongest expressed by a group of human melanomas. We have no demonstrated that this antibody can mediate antibody-dependent cellular cytotoxicity (ADCC) to human melanoma cells expressing antigen 3., and that lymphocytes from human peripheral blood can be used as the source of K cells. A monoclonal IgG1 antibody, 3.1, to the same determinant of antigen 3.1 gave only weak and inconsistent ADCC.

Citing Articles

Diagnostic and therapeutic use of monoclonal antibodies to human tumor antigens.

Hellstrom K, Hellstrom I, Brown J Med Oncol Tumor Pharmacother. 1984; 1(3):143-7.

PMID: 6400036 DOI: 10.1007/BF02934135.

Immunochemical characterization of a human high molecular weight--melanoma associated antigen identified with monoclonal antibodies.

Wilson B, Ruberto G, Ferrone S Cancer Immunol Immunother. 1983; 14(3):196-201.

PMID: 6188530 PMC: 11039124. DOI: 10.1007/BF00205360.

Human tumor-associated antigens identified by monoclonal antibodies.

Hellstrom K, Hellstrom I, Brown J Springer Semin Immunopathol. 1982; 5(2):127-46.

PMID: 6183764 DOI: 10.1007/BF00199792.

Importance of immunoglobulin isotype in human antibody-dependent, cell-mediated cytotoxicity directed by murine monoclonal antibodies.

Kipps T, Parham P, Punt J, Herzenberg L J Exp Med. 1985; 161(1):1-17.

PMID: 3918141 PMC: 2187540. DOI: 10.1084/jem.161.1.1.

Strong antitumor activities of IgG3 antibodies to a human melanoma-associated ganglioside.

Hellstrom I, Brankovan V, Hellstrom K Proc Natl Acad Sci U S A. 1985; 82(5):1499-502.

PMID: 3856277 PMC: 397290. DOI: 10.1073/pnas.82.5.1499.