Comparison of the Antimuscarinic Activity of Mianserin and Amitriptyline in the Cat Superior Cervical Ganglion

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 1981 Apr 1

PMID 6165898

Citations 1

Authors

Y H Kwok

F Mitchelson

Affiliations

Soon will be listed here.

Abstract

The antimuscarinic activity of mianserin and amitriptyline was investigated in the cat superior cervical ganglion using McN-A-343 as a muscarinic agonist. Mianserin was found to have a similar order of potency to amitriptyline in this preparation, in contrast to the marked difference in their antimuscarinic activities on non-neuronal muscarinic receptors. These findings suggest that the action of mianserin on neuronal muscarinic receptors is more important than that predicted from studies on non-neuronal receptors and may be related to its anti-depressant activity.

Citing Articles

The effect of some antidepressants on prejunctional muscarinic receptors on the sympathetic nerves of the isolated rabbit ear artery.

Kwok Y, Mitchelson F Naunyn Schmiedebergs Arch Pharmacol. 1982; 320(1):14-9.

PMID: 6289134 DOI: 10.1007/BF00499065.

References

TAKESHIGE C, Volle R . SIMILARITIES IN THE GANGLIONIC ACTIONS OF CALCIUM IONS AND ATROPINE. J Pharmacol Exp Ther. 1964; 145:173-80. View

Wamsley J, Black Jr A, Redick J, West J, Williams T . SIF cells, cyclic AMP responses, and catecholamines of the guinea pig superior cervical ganglion. Brain Res. 1978; 156(1):75-82. DOI: 10.1016/0006-8993(78)90080-x. View

KADZIELAWA K, GAWECKA I, Kadzielawa R . The potentiating influence of imipramine on ganglionic effects of catecholamines. Int J Neuropharmacol. 1968; 7(6):517-21. View

Pinder R, Brogden R, Speight T, Avery G . Viloxazine: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs. 1977; 13(6):401-21. DOI: 10.2165/00003495-197713060-00001. View

CAIRNCROSS K, McCulloch M, Story D, Trinker F . Modification of synaptic transmission in the superior cervical ganglion by epinephrine, norepinephrine and nortriptyline. Int J Neuropharmacol. 1967; 6(4):293-300. DOI: 10.1016/0028-3908(67)90018-4. View

Weinstock M, Cohen D . Tricyclic antidepressant drugs as antagonists of muscarinic receptors in sympathetic ganglia. Eur J Pharmacol. 1976; 40(2):321-8. DOI: 10.1016/0014-2999(76)90069-8. View

de Groat W, Volle R . The actions of the catecholamines on transmission in the superior cervical ganglion of the cat. J Pharmacol Exp Ther. 1966; 154(1):1-13. View

Fisher A, Weinstock M, GITTER S, Cohen S . A new probe for heterogeneity in muscarinic receptors: 2-methyl-spiro-(1, 3-dioxolane-4, 3')-quinuclidine. Eur J Pharmacol. 1976; 37(2):329-38. DOI: 10.1016/0014-2999(76)90041-8. View

Brogden R, Heel R, Speight T, Avery G . Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs. 1978; 16(4):273-301. DOI: 10.2165/00003495-197816040-00001. View

10.

ROBSON R, Antonaccio M, SAELENS J, Liebman J . Antagonism by mianserin and classical alpha-adrenoceptor blocking drugs of some cardiovascular and behavioral effects of clonidine. Eur J Pharmacol. 1978; 47(4):431-42. DOI: 10.1016/0014-2999(78)90124-3. View

11.

DEGROAT W, Volle R . GANGLIONIC ACTIONS OF OXOTREMORINE. Life Sci (1962). 1963; 8:618-23. DOI: 10.1016/0024-3205(63)90116-4. View

12.

Doggrell S . Mianserin potentiates responses to acetylcholine in the rat anococcygeus muscle. Eur J Pharmacol. 1979; 55(3):311-4. DOI: 10.1016/0014-2999(79)90199-7. View

13.

Porsolt R, Anton G, Blavet N, JALFRE M . Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol. 1978; 47(4):379-91. DOI: 10.1016/0014-2999(78)90118-8. View

14.

Vargaftig B, COIGNET J, de Vos C, Grijsen H, Bonta I . Mianserin hydrochloride: peripheral and central effects in relation to antagonism against 5-hydroxytryptamine and tryptamine. Eur J Pharmacol. 1971; 16(3):336-46. DOI: 10.1016/0014-2999(71)90036-7. View

15.

RANDRUP A, Braestrup C . Uptake inhibition of biogenic amines by newer antidepressant drugs: relevance to the dopamine hypothesis of depression. Psychopharmacology (Berl). 1977; 53(3):309-14. DOI: 10.1007/BF00492370. View

16.

Doxey J, Everitt J, Metcalf G . Mianserin--an analysis of its peripheral autonomic actions. Eur J Pharmacol. 1978; 51(1):1-10. DOI: 10.1016/0014-2999(78)90055-9. View

17.

Frankhuyzen A, Bonta I . Effect of mianserin, a potent anti-serotonin agent, on the isolated rat stomach fundus preparation. Eur J Pharmacol. 1974; 25(1):40-50. DOI: 10.1016/0014-2999(74)90092-2. View

18.

Browne R . Effects of antidepressants and anticholinergics in a mouse "behavioral despair" test. Eur J Pharmacol. 1979; 58(3):331-4. DOI: 10.1016/0014-2999(79)90483-7. View

19.

Fisher A, Grunfeld Y, Weinstock M, GITTER S, Cohen S . A study of muscarinic receptor heterogeneity with weak antagonists. Eur J Pharmacol. 1976; 38(1):131-9. DOI: 10.1016/0014-2999(76)90209-0. View

20.

Jaramillo J, Volle R . Nonmuscarinic stimulation and block of a sympathetic ganglion by 4-(m-chlorophenylcarbamoyloxy)-2-butynyltrimethylammonium chloride (McN-A-343). J Pharmacol Exp Ther. 1967; 157(2):337-45. View