Interferon Action: RNA Cleavage Pattern of a (2'-5')oligoadenylate--dependent Endonuclease

Overview

Journal Science

Specialty Science

Date 1981 May 29

PMID 6165080

Citations 125

Authors

E Slattery

P Lengyel

Affiliations

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Abstract

One of the mediators of interferon action is a latent endoribonuclease (ribonuclease L) that is activated by (2'-5')oligoadenylates. Among the homopolymers of the four common ribonucleotides, activated ribonuclease L degrades at an appreciable rate only polyuridylic acid. In two natural RNA's tested the most frequent ribonuclease L cleavages occur after UA, UG, and UU (A, adenine; U, uracil; and G, guanine) and much less frequent cleavages after CA and AC (C, cytosine).

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