Serologic and Immunochemical Characterization of the Specificity of Four Monoclonal Antibodies to Distinct Antigenic Determinants Expressed on Subpopulations of Human Ia-like Antigens

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 1981 Feb 1

PMID 6161181

Citations 34

Authors

V Quaranta

M A Pellegrino

S Ferrone

Affiliations

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Abstract

Serologic and immunochemical assays showed that the monoclonal antibodies Q2/70, Q2/80, Q5/6, and Q5/13 react with human Ia-like antigens. Each monoclonal antibody recognizes distinct antigenic determinants that are different from those defining the serologic polymorphism of Ia-like antigens defined by conventional alloantisera and are expressed on subpopulations of Ia-like antigens. The determinants recognized by the MoAb Q2/70 and Q5/13 are expressed on all HLA-DR allospecificities tested, whereas those reacting with the MoAb Q2/80 and Q5/6 are not detectable on HLA-DR5 and HLA-DR7 allospecificities, respectively.

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