The Effect of Exogenous Interferon: Acceleration of Autoimmune and Renal Diseases in (NZB/W) F1 Mice

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1980 May 1

PMID 6160000

Citations 23

Authors

C Adam

Y Thoua

P Ronco

P Verroust

M Tovey

L MOREL-MAROGER

Affiliations

Soon will be listed here.

Abstract

To determine the effect of prolonged administration of exogenous interferon on the autoimmune disease of NZB/W female mice, forty-four NZB/W mice received three injections per week of 6.4 x 10(4) interferon units from birth to 33 weeks, forty mice were injected with mock interferon and forty-eight mice were left untreated. In mice injected with interferon growth was delayed, survival was decreased, and the severity of the glomerulonephritis was enhanced. Interferon increased the titre of serum anti-ssDNA and anti-soluble nucleoprotein antibodies, but had no effect on the circulating immune complex load. These results suggest that interferon in some way affects local deposition of immune complexes within the glomerulus.

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References

Lambert P, Dixon F . Pathogenesis of the glomerulonephritis of NZB/W mice. J Exp Med. 1968; 127(3):507-22. PMC: 2138462. DOI: 10.1084/jem.127.3.507. View

Steinberg A, Baron S, Talal N . The pathogenesis of autoimmunity in New Zealand mice, I. Induction of antinucleic acid antibodies by polyinosinic-polycytidylic acid. Proc Natl Acad Sci U S A. 1969; 63(4):1102-7. PMC: 223434. DOI: 10.1073/pnas.63.4.1102. View

Lambert P, Dixon F . Genesis of antinuclear antibody in NZB-W mice: role of genetic factors and of viral infections. Clin Exp Immunol. 1970; 6(6):829-39. PMC: 1712825. View

Carpenter D, Steinberg A, Schur P, Talal N . The pathogenesis of autoimmunity in New Zealand mice. II. Acceleration of glomerulonephritis by polyinosinic-polycytidylic acid. Lab Invest. 1970; 23(6):628-34. View

MELLORS R, Shirai T, Aoki T, HUEBNER R, Krawczynski K . Wild-type Gross leukemia virus and the pathogenesis of the glomerulonephritis of New Zealand mice. J Exp Med. 1971; 133(1):113-32. PMC: 2138888. DOI: 10.1084/jem.133.1.113. View

Gabriel R . 1-Methylisatin 3-thiosemicarbazone treatment of NZB x NZW hybrid mice. Br J Exp Pathol. 1971; 52(3):271-5. PMC: 2072325. View

Benveniste J, Henson P, Cochrane C . Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils, and a platelet-activating factor. J Exp Med. 1972; 136(6):1356-77. PMC: 2139324. DOI: 10.1084/jem.136.6.1356. View

Billiau A, SOBIS H, DE SOMER P . Influence of interferon on virus particle formation in different oncornavirus carrier cell lines. Int J Cancer. 1973; 12(3):646-53. DOI: 10.1002/ijc.2910120313. View

Tovey M, GRESSER I . A method for the large scale production of potent interferon preparations. Proc Soc Exp Biol Med. 1974; 146(3):809-15. DOI: 10.3181/00379727-146-38196. View

10.

Friedman R, Chang E, Ramseur J, Myers M . Interferon-directed inhibition of chronic murine leukemia virus production in cell cultures: lack of effect on intracellular viral markers. J Virol. 1975; 16(3):569-74. PMC: 354704. DOI: 10.1128/JVI.16.3.569-574.1975. View

11.

Theofilopoulos A, Wilson C, Dixon F . The Raji cell radioimmune assay for detecting immune complexes in human sera. J Clin Invest. 1976; 57(1):169-82. PMC: 436637. DOI: 10.1172/JCI108257. View

12.

GRESSER I, Maury C, Tovey M, MOREL-MAROGER L, Pontillon F . Progressive glomerulonephritis in mice treated with interferon preparations at birth. Nature. 1976; 263(5576):420-2. DOI: 10.1038/263420a0. View

13.

Klassen L, Budman D, Williams G, Steinberg A, Gerber N . Ribavirin: efficacy in the treatment of murine autoimmune disease. Science. 1977; 195(4280):787-9. DOI: 10.1126/science.299957. View

14.

Imamura M, MELLORS R, Strand M, August J . Murine Type C viral envelope glycoprotein gp69/71 and lupus-like glomerulonephritis of New Zealand mice. An immunoperoxidase study. Am J Pathol. 1977; 86(2):375-86. PMC: 2032091. View

15.

Walker S . Accelerated mortality in young NZB/NZW mice treated with the interferon inducer tilorone hydrochloride. Clin Immunol Immunopathol. 1977; 8(2):204-12. DOI: 10.1016/0090-1229(77)90110-6. View

16.

GRESSER I . On the varied biologic effects of interferon. Cell Immunol. 1977; 34(2):406-15. DOI: 10.1016/0008-8749(77)90262-3. View

17.

Datta S, Manny N, Andrzejewski C, Andre-Schwartz J, Schwartz R . Genetic studies of autoimmunity and retrovirus expression in crosses of New Zealand black mice I. Xenotropic virus. J Exp Med. 1978; 147(3):854-71. PMC: 2184200. DOI: 10.1084/jem.147.3.854. View

18.

Datta S, McCONAHEY P, Manny N, Theofilopoulos A, Dixon F, Schwartz R . Genetic studies of autoimmunity and retrovirus expression in crosses of New Zealand black mice. II. The viral envelope glycoprotein gp70. J Exp Med. 1978; 147(3):872-81. PMC: 2184189. DOI: 10.1084/jem.147.3.872. View

19.

Gresser J, MOREL-MAROGER L, Verroust P, Riviere Y, GUILLON J . Anti-interferon globulin inhibits the development of glomerulonephritis in mice infected at birth with lymphocytic choriomeningitis virus. Proc Natl Acad Sci U S A. 1978; 75(7):3413-6. PMC: 392787. DOI: 10.1073/pnas.75.7.3413. View

20.

Heremans H, Billiau A, Colombatti A, Hilgers J, DE SOMER P . Interferon treatment of NZB mice: accelerated progression of autoimmune disease. Infect Immun. 1978; 21(3):925-30. PMC: 422085. DOI: 10.1128/iai.21.3.925-930.1978. View