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[Radical Operation and Recurrence Prevention with Azulfidine in Crohn Disease: a Prospective Multicenter Study--initial Results]

Overview
Journal Langenbecks Arch Chir
Specialty General Surgery
Date 1984 Jan 1
PMID 6150408
Citations 4
Authors
K Ewe
H Malchow
C Herfarth
Affiliations
Soon will be listed here.
Abstract

The influence of radical versus more restricted operation and Azulfidine prophylaxis was studied in a controlled, partially randomized double blind multicenter trial (16 centres) in 177 patients over 3 years. Early relapse occurred more frequently in the radically operated group (49 vs. 31%) and less frequently under Azulfidine prophylaxis (34 vs. 46%). The radical operation had no advantage over the more restricted procedure and should be abandoned in Crohn's disease.

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References
1.
WENCKERT A, Kristensen M, EKLUND A, BARANY F, Jarnum S, Worning H . The long-term prophylactic effect of salazosulphapyridine (Salazopyrin) in primarily resected patients with Crohn's disease. A controlled double-blind trial. Scand J Gastroenterol. 1978; 13(2):161-7. DOI: 10.3109/00365527809181743. View
2.
Mekhjian H, SWITZ D, Watts H, Deren J, Katon R, BEMAN F . National Cooperative Crohn's Disease Study: factors determining recurrence of Crohn's disease after surgery. Gastroenterology. 1979; 77(4 Pt 2):907-13. View
3.
Hulten L . [Early surgery in Crohn's disease, yes or no?]. Internist (Berl). 1979; 20(4):171-5. View
4.
Best W, Becktel J, SINGLETON J, KERN Jr F . Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology. 1976; 70(3):439-44. View
5.
Lee E . Aim of surgical treatment of Crohn's disease. Gut. 1984; 25(3):217-22. PMC: 1432276. DOI: 10.1136/gut.25.3.217. View